摄入咖啡与免疫球蛋白A肾病的孟德尔随机化研究  

Mendelian Randomization Study on Coffee Intake and Immunoglobulin A Nephropathy

作　　者：张晓倩 王艺涵 樊均明 Zhang Xiaoqian;Wang Yihan;Fan Junming(Department of Nephrology,The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou 646000,China;Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]西南医科大学附属中医医院肾病科,泸州646000 [2]成都医学院,成都610500

出　　处：《成都医学院学报》2025年第1期37-40,共4页Journal of Chengdu Medical College

基　　金：四川省科学技术厅科技计划项目(No:2021YFS0035)。

摘　　要：目的利用孟德尔随机化(MR)方法探讨摄入咖啡与免疫球蛋白A肾病(IgAN)发生的因果关系。方法从全基因组关联分析(GWAS)研究数据库中提取与咖啡摄入相关的单核苷酸多态性位点(SNP)作为工具变量,用逆方差加权法(IVW)、加权中位法、加权分析、MR-Egger法、简单分析法进行两样本MR分析,评价摄入咖啡与IgAN的因果关系。结果筛选到30个相关SNP,IVW结果表明咖啡摄入与IgAN风险间不存在因果关系(OR=0.887,95%CI:0.591~1.329),加权中位法结果表明咖啡摄入与IgAN风险间不存在因果关系(OR=1.051,95%CI:0.625~1.760),加权分析结果表明咖啡摄入与IgAN风险间不存在因果关系(OR=1.063,95%CI:0.612~1.844),MR-Egger分析结果表明咖啡摄入与IgAN风险间不存在因果关系(OR=1.298,95%CI:0.531~3.172),简单分析结果表明咖啡摄入与IgAN风险间不存在因果关系(OR=0.815,95%CI:0.316~2.098),敏感性分析显示研究结果没有产生偏倚,异质性检验表明SNP不存在异质性。结论摄入咖啡与IgAN之间不存在因果关系。Objective To investigate the causal relationship between coffee intake and the incidence of immunoglobulin A nephropathy(IgAN)using the Mendelian randomization(MR)method.Methods Single nucleotide polymorphisms(SNPs)associated with coffee consumption were extracted from genome-wide association studies(GWAS)as instrumental variables.Two-sample MR analyses were performed using inverse variance weighting(IVW),weighted median method,weighted analysis,MR-Egger method,and simple analysis to evaluate the causal relationship between coffee consumption and IgAN.Results Thirty relevant SNPs were identified.The IVW results showed no causal relationship between coffee consumption and the risk of IgAN(OR=0.887,95%CI:0.591-1.329).The weighted median method indicated no causal relationship(OR=1.051,95%CI:0.625-1.760).Weighted analysis similarly showed no causal relationship(OR=1.063,95%CI:0.612-1.844).MR-Egger analysis also revealed no causal relationship(OR=1.298,95%CI:0.531-3.172).And simple analysis results confirmed no causal relationship(OR=0.815,95%CI:0.316-2.098).Sensitivity analysis indicated no bias in the results,and heterogeneity tests showed no heterogeneity among SNPs.Conclusion There is no causal relationship between coffee consumption and IgAN.

关 键 词：咖啡摄入 免疫球蛋白A肾病 孟德尔随机化 全基因组关联分析 

分 类 号：R692.5[医药卫生—泌尿科学] R96[医药卫生—外科学]