血清GDF-15、S100A12对儿童急性白血病化疗后中性粒细胞缺乏伴发热的诊断价值  

Diagnostic Value of Serum GDF-15 and S100A12 for Neutropenia Accompanied by Fever After Chemotherapy in Children with Acute Leukemia

作　　者：许静静[1] 李岩[1] 李健[1] 赵燕 Xu Jingjing;Li Yan;Li Jian;Zhao Yan(Department of Blood Transfusion,Affiliated Hospital of Jining Medical University,Jining 272000,China)

机构地区：[1]济宁医学院附属医院输血科,济宁272000

出　　处：《成都医学院学报》2025年第1期131-135,共5页Journal of Chengdu Medical College

摘　　要：目的探究血清生长分化因子15(GDF-15)、钙粒蛋白C(S100A12)对儿童急性白血病化疗后中性粒细胞缺乏伴发热的诊断价值。方法将2022年1月至2024年1月济宁医学院附属医院收治的120例儿童急性白血病化疗后中性粒细胞缺乏伴发热患儿作为试验组,将同期收治的138例儿童急性白血病化疗后未发生中性粒细胞缺乏伴发热患儿作为对照组。酶联免疫吸附法(ELISA)检测两组患儿血清GDF-15、S100A12表达水平。Pearson法分析血清GDF-15、S100A12表达与儿童急性白血病化疗后中性粒细胞缺乏伴发热患儿临床资料的相关性。采用多因素Logistic回归分析儿童急性白血病化疗后中性粒细胞缺乏伴发热的影响因素。绘制受试者工作特征(ROC)曲线分析血清GDF-15、S100A12表达水平对儿童急性白血病化疗后中性粒细胞缺乏伴发热的诊断价值。结果与对照组相比,试验组血红蛋白、中性粒细胞、白细胞计数、血小板计数均降低(P<0.05),血清GDF-15、S100A12表达均升高(P<0.05)。血清GDF-15、S100A12表达与中性粒细胞缺乏伴发热患儿的血红蛋白、中性粒细胞、白细胞计数、血小板计数均呈负相关(P<0.05)。血红蛋白、中性粒细胞、白细胞计数、血小板计数均为患儿中性粒细胞缺乏伴发热的保护因素(P<0.05),血清GDF-15、S100A12为危险因素(P<0.05)。血清GDF-15、S100A12表达诊断儿童急性白血病化疗后中性粒细胞缺乏伴发热的曲线下面积(AUC)分别为0.950、0.907,二者联合诊断的AUC为0.980,大于GDF-15(Z=2.159,P=0.031)、S100A12(Z=3.780,P<0.001)单独诊断的AUC。结论儿童急性白血病化疗后中性粒细胞缺乏伴发热患儿血清GDF-15、S100A12表达升高,二者联合具有较高的中性粒细胞缺乏伴发热诊断价值。Objective To explore the diagnostic value of serum levels of growth differentiation factor 15(GDF-15)and calgranulin C(S100A12)for neutropenia accompanied by fever after chemotherapy in children with acute leukemia.Methods In this study,120 acute leukemia children with neutropenia accompanied by fever after chemotherapy admitted to the Affiliated Hospital of Jining Medical University from January 2022 to January 2024 were included in the experimental group,and 138 acute leukemia children without neutropenia accompanied by fever after chemotherapy were included in the control group.Enzyme linked immunosorbent assay(ELISA)was utilized to detect the serum levels of GDF-15 and S100A12 of children in both groups.Pearson method was employed to analyze the correlation between serum GDF-15 and S100A12 levels with the clinical data of acute leukemia children with neutropenia accompanied by fever after chemotherapy.Multivariate Logistic regression was used to analyze the influencing factors of neutropenia accompanied by fever in children with acute leukemia after chemotherapy.Receiver operating characteristic(ROC)curve was plotted to analyze the diagnostic value of serum GDF-15 and S100A12 levels for neutropenia accompanied by fever in children with acute leukemia after chemotherapy.Results Compared with the control group,the experimental group showed a decrease in hemoglobin(Hb),neutrophil count,white blood cell(WBC)count,and platelet count(P<0.05),but an increase in serum GDF-15 and S100A12 levels(P<0.05).The serum levels of GDF-15 and S100A12 were negatively correlated with Hb,neutrophil count,WBC count,and platelet count in children with neutropenia accompanied by fever(P<0.05).Hb,neutrophil count,WBC count,and platelet count were all protective factors for neutropenia accompanied by fever in children(P<0.05),while serum GDF-15 and S100A12 were risk factors(P<0.05).The areas under the curve(AUCs)of serum GDF-15 and S100A12 levels for diagnosing neutropenia accompanied by fever in children with acute leukemia after chem

关 键 词：儿童急性白血病 中性粒细胞缺乏伴发热 生长分化因子15 钙粒蛋白C 诊断 

分 类 号：R733.71[医药卫生—肿瘤]