Low-concentration atropine(0.01%)on quantitative contrast sensitivity function in Chinese children with myopia  

作　　者：Yu-Hao Ye Yi-Yong Xian Fang Liu Zhong-Lin Lyu Xing-Tao Zhou Jing Zhao 

机构地区：[1]Department of Ophthalmology and Optometry,Eye&ENT Hospital of Fudan University,Shanghai 200031,China [2]NHC Key Laboratory of Myopia(Fudan University),Key Laboratory of Myopia,Chinese Academy of Medical Sciences,Shanghai 200000,China [3]Shanghai Research Center of Ophthalmology and Optometry,Shanghai 200000,China [4]Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care(20DZ2255000).Shanghai 200030,China [5]Division of Arts and Sciences,NYU Shanghai,Shanghai 200000,China [6]Center for Neural Science and Department of Psychology,New York University,New York 10012,USA [7]NYU-ECNU Institute of Brain and Cognitive Science,NYU Shanghai,Shanghai 200000,China

出　　处：《International Journal of Ophthalmology(English edition)》2025年第1期117-124,共8页国际眼科杂志(英文版)

基　　金：Supported by National Key Research and Development Program of China(No.2023YFA0915000)。

摘　　要：AIM:To investigate the effect of 0.01%low-concentration atropine(LA)on quantitative contrast sensitivity function(qCSF)in children with myopia.METHODS:This paired case-control study included 90 eyes of 58 children who were sex-,age-,and refractionmatched and equally divided into two groups:the 0.01%LA group had undergone 6mo use of daily 0.01%atropine and control group was naïve to LA.Routine ophthalmic examinations and qCSF test without refractive correction were performed.Two groups were compared in monocular and binocular qCSF parameters,including the area under logCSF,CSF acuity,and contrast sensitivity(CS)at 1.0-18.0 cycle per degree(cpd).RESULTS:In the monocular comparison,the CSF acuity of the LA group was significantly higher than that of the control group(7.58±5.51 vs 6.37±4.22 cpd,P<0.05).The subgroup analysis showed that in the 6-9y group,CSF acuity was significantly higher in the LA group than the control group(8.76±6.19 vs 6.54±4.25 cpd,P<0.05),and in the Female group,low refraction sphere group,and high refraction cylinder group,the CS at high spatial frequencies(12.0 and 18.0 cpd)were significantly higher in the LA group than in the control group(all P<0.05).In the binocular test,CSF acuity and CS at 12.0 cpd were significantly higher in the LA group than in the control group(10.95±7.00 vs 8.65±5.12 cpd;0.17±0.33 vs 0.06±0.16,respectively;both P<0.05).CONCLUSION:Use of LA may result in improved CS in children with early onset myopia.

关 键 词：low-concentration atropine MYOPIA quantitative contrast sensitivity function Chinese children 

分 类 号：R72[医药卫生—儿科]