Clinical profile and outcomes of ocular surface squamous neoplasia at the Philippine General Hospital:a retrospective study  

作　　者：Mary Ellaine S.Diaz Ruben Lim Bon Siong Justin Alan Yao Gary John V.Mercado 

机构地区：[1]Department of Ophthalmology and Visual Sciences,University of the Philippines Manila-Philippine General Hospital,Manila 1000,Philippines [2]Eye Institute,St.Luke’s Medical Center,Quezon City,Manila 1112,Philippines [3]Eye and Vision Institute,The Medical City,Pasig 1800,Philippines

出　　处：《International Journal of Ophthalmology(English edition)》2025年第1期132-138,共7页国际眼科杂志(英文版)

摘　　要：AIM:To evaluate the demographics,clinical characteristics,treatments,and outcomes of patients with ocular surface squamous neoplasia(OSSN)at the Philippine General Hospital.METHODS:This was a single-center,11-year retrospective,cross sectional case series on 18 cases of OSSN seen between January 2012 to June 2023.The patient’s demographics,presenting symptoms,tumor characteristics,histopathologic diagnosis,treatment,outcomes,and duration of follow-up were reviewed.RESULTS:Out of 33 identified cases of OSSN,only 18 were eligible for inclusion in the study.Mean age was 60.78y(range 31 to 80),with male predominance(66.67%).The left eye was most commonly affected(61.11%)with most presenting with fleshy mass(83.33%).Most tumors were located nasally(66.67%)and were predominantly papilliform(44.44%)in morphology with associated hyperpigmentation(38.89%).Squamous cell carcinoma(SCCA)was the most common histopathologic diagnosis(72.22%).The main primary treatment was surgical excision(94.44%)with or without adjunctive therapy,with only 1 patient undergoing first-line topical chemotherapy.Only 3 recurrences(16.67%)were noted with a median followup of 7.5mo.A statistically significant recurrence-free odds leaning towards the utilization of cryotherapy was noted.CONCLUSION:OSSN seen at the Philippine General Hospital is presented as a limbal papilliform mass,most commonly affecting elderly males.Surgical excision with adjuvant cryotherapy and/or chemotherapy is the preferred mode of treatment.

关 键 词：ocular surface squamous neoplasia conjunctival malignancy squamous cell carcinoma conjunctival intraepithelial neoplasia 

分 类 号：R73[医药卫生—肿瘤]