蚓激酶联合依达拉奉治疗急性脑梗死患者的效果  

Effects of Lumbrokinase combined with Edaravone in treatment of patients with acute cerebral infarction

作　　者：孟迪 MENG Di(Second Department of Internal Medicine of the Third Affiliated Hospital of Luohe Medical College,Luohe 462000 Henan,China)

机构地区：[1]漯河医学高等专科学校第三附属医院内二科,河南漯河462000

出　　处：《中国民康医学》2025年第1期17-20,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察蚓激酶联合依达拉奉治疗急性脑梗死(ACI)患者的效果。方法:回顾性分析2021—2022年该院收治的62例ACI患者的临床资料,按照治疗方法不同将其分为观察组与对照组各31例。两组均进行常规治疗,在此基础上,对照组予以依达拉奉治疗,观察组在对照组基础上联合蚓激酶治疗,两组均持续治疗14 d。比较两组临床疗效,治疗前后神经功能缺损[美国国立卫生研究院卒中量表(NIHSS)]评分、日常生活能力[Barthel指数(BI)]评分、凝血功能指标[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)]水平、血清学指标[血管内皮生长因子(VEGF)、可溶性血管细胞黏附分子-1(SVCAM-1)]水平,以及不良反应发生率。结果:观察组治疗总有效率为96.77%(30/31),高于对照组的74.19%(23/31),差异有统计学意义(P<0.05);治疗后,两组NIHSS评分均低于治疗前,且观察组低于对照组,两组BI评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组APTT、PT均长于治疗前,且观察组长于对照组,两组FIB水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组VEGF水平均高于治疗前,且观察组高于对照组,两组SVCAM-1水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:蚓激酶联合依达拉奉治疗ACI患者可提高治疗总有效率和日常生活能力评分,降低神经功能缺损评分,改善凝血功能指标和血清学指标水平,效果优于单纯依达拉奉治疗。Objective:To observe effects of Lumbrokinase combined with Edaravone in treatment of patients with acute cerebral infarction(ACI).Methods:The clinical data of 62 patients with ACI admitted to this hospital from 2021 to 2022 were retrospectively analyzed.According to different treatment methods,they were divided into observation group and control group,31 cases in each group.Both groups received routine treatment.On this basis,the control group was treated with Edaravone,while the observation group was treated with Lumbrokinase on the basis of that of the control group.Both groups were treated for 14 d.The clinical efficacy,the neurological deficit[National Institutes of Health stroke scale(NIHSS)]score,the daily living ability[Barthel index(BI)]score,the coagulation function index[activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(FIB)]levels,the serological index[vascular endothelial growth factor(VEGF),soluble vascular cell adhesion molecule-1(SVCAM-1)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.77%(30/31),which was higher than 74.19%(23/31)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS scores of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;the BI scores of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the APTT and PT in the two groups were longer than those before the treatment,and those in the observation group were longer than those in the control group;the FIB levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically

关 键 词：急性脑梗死 蚓激酶 依达拉奉 神经功能缺损 日常生活能力 凝血功能 不良反应 

分 类 号：R743.3[医药卫生—神经病学与精神病学]