地衣芽孢杆菌联合复方谷氨酰胺治疗溃疡性结肠炎患者的效果  

Effects of Bacillus licheniformis combined with Compound glutamine in treatment of patients with ulcerative colitis

作　　者：张晓静 ZHANG Xiaojing(Department of Gastroenterology of Xinmi Hospital of Traditional Chinese Medicine,Zhengzhou 452370 Henan,China)

机构地区：[1]新密市中医院消化内科,河南郑州452370

出　　处：《中国民康医学》2025年第1期34-36,40,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察地衣芽孢杆菌联合复方谷氨酰胺治疗溃疡性结肠炎(UC)患者的效果。方法:回顾性分析2020年1月至2023年9月该院收治的60例UC患者的临床资料,按照治疗方法不同将其分为对照组和研究组各30例。两组均进行基础治疗,在此基础上,对照组予以复方谷氨酰胺治疗,研究组在对照组基础上联合地衣芽孢杆菌治疗,两组均连续治疗4周。比较两组临床疗效,治疗前后肠道菌群数量、肠黏膜屏障功能指标[D-乳酸(D-LA)、二胺氧化酶(DAO)]水平、血清学指标[超敏C反应蛋白(hs-CRP)、白细胞介素-8(IL-8)、黏蛋白1(MUC1)、C-C基序趋化因子配体11(CCL11)]水平,以及不良反应发生率。结果:研究组治疗总有效率为96.67%(29/30),高于对照组的73.33%(22/30),差异有统计学意义(P<0.05);治疗后,两组乳酸杆菌、双歧杆菌数量均多于治疗前,且研究组多于对照组,两组大肠埃希菌数量均少于治疗前,且研究组少于对照组,差异有统计学意义(P<0.05);治疗后,两组DAO、D-LA水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组hs-CRP、IL-8、MUC1、CCL11水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:地衣芽孢杆菌联合复方谷氨酰胺治疗UC患者可提高治疗总有效率,调节肠道菌群数量,降低肠黏膜屏障功能指标和血清学指标水平,效果优于单纯复方谷氨酰胺治疗。Objective:To observe effects of Bacillus licheniformis combined with Compound glutamine in treatment of patients with ulcerative colitis(UC).Methods:The clinical data of 60 patients with UC admitted to this hospital from January 2020 to September 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and study group,30 cases in each group.Both groups received basic treatment.On this basis,the control group was treated with Compound glutamine,while the study group was treated with Bacillus licheniformis on the basis of that of the control group.Both groups were treated for 4 weeks.The clinical efficacy,the number of intestinal flora,the levels of intestinal mucosal barrier function indexes[D-lactic acid(D-LA),diamine oxidase(DAO)]and serological indexes[hypersensitive C-reactive protein(hs-CRP),interleukin-8(IL-8),mucin 1(MUC1),C-C motif chemokine ligand 11(CCL11)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 96.67%(29/30),which was higher than 73.33%(22/30)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the number of Lactobacillus and Bifidobacterium in the two groups was more than that before the treatment,and that in the study group was more than that in the control group;the number of Escherichia coli in the two groups was less than that before the treatment,and that in the study group was less than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of DAO and D-LA in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of hs-CRP,IL-8,MUC1 and CCL11 in the two groups were lower than those before the treatment,those in the study group were lower than those in the con

关 键 词：溃疡性结肠炎 地衣芽孢杆菌 复方谷氨酰胺 肠道菌群 肠黏膜屏障功能 不良反应 

分 类 号：R574.62[医药卫生—消化系统]