调强放疗联合同步化疗在食管癌患者中的应用效果  

Application effects of intensity modulated radiotherapy combined with concurrent chemotherapy in patients with esophageal cancer

作　　者：陈琼 张战胜 王合望 CHEN Qiong;ZHANG Zhansheng;WANG Hewang(Department of Oncology of Zhumadian Tong’an Tumor Hospital,Zhumadian 463000 Henan,China)

机构地区：[1]驻马店桐安肿瘤医院肿瘤内科,河南驻马店463000

出　　处：《中国民康医学》2025年第1期37-40,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察调强放疗联合同步化疗在食管癌患者中的应用效果。方法:回顾性分析2020年6月至2022年6月该院收治的72例食管癌患者的临床资料,按照治疗方法不同将其分为观察组和对照组各36例。对照组予以常规放疗联合同步化疗,观察组予以调强放疗联合同步化疗。比较两组临床疗效,治疗前后Karnofsky功能状态(KPS)评分、肿瘤标志物[胰岛素样生长因子-1(IGF-1)、癌胚抗原(CEA)、血管内皮生长因子(VEGF)]水平,以及不良反应发生率。结果:观察组客观缓解率(ORR)为91.67%(33/36),高于对照组的72.22%(26/36),差异有统计学意义(P<0.05);治疗后,两组KPS评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组IGF-1、CEA、VEGF水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组骨髓抑制、胃肠道反应发生率比较,差异均无统计学意义(P>0.05);观察组放射性食管炎、放射性肺炎发生率为22.22%(8/36)、16.67%(6/36),分别低于对照组的50.00%(18/36)、41.67%(15/36),差异均有统计学意义(P<0.05)。结论:调强放疗联合同步化疗应用于食管癌患者可提高ORR和KPS评分,降低肿瘤标志物水平和放射性食管炎、放射性肺炎发生率,效果优于常规放疗联合同步化疗。Objective:To observe application effects of intensity modulated radiotherapy combined with concurrent chemotherapy in patients with esophageal cancer.Methods:The clinical data of 72 patients with esophageal cancer admitted to this hospital from June 2020 to June 2022 were retrospectively analyzed.According to different treatment methods,they were divided into observation group and control group,36 cases in each group.The control group was treated with conventional radiotherapy combined with concurrent chemotherapy,while the observation group was treated with intensity modulated radiotherapy combined with concurrent chemotherapy.The clinical efficacy,the Karnofsky performance status(KPS)score and the tumor markers[insulin-like growth factor-1(IGF-1),carcinoembryonic antigen(CEA),vascular endothelial growth factor(VEGF)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The objective remission rate(ORR)of the observation group was 91.67%(33/36),which was higher than 72.22%(26/36)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the KPS scores of the two groups were higher than those before the treatment,that in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IGF-1,CEA and VEGF in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of bone marrow suppression and gastrointestinal reactions between the two groups(P>0.05).The incidence of radiation esophagitis and radiation pneumonitis in the observation group were 22.22%(8/36)and 16.67%(6/36),respectively,which were lower than 50.00%(18/36)and 41.67%(15/36)in the control group,and the differences were statistically significant(P<0.05).Conclusions:Intensity

关 键 词：食管癌 调强放疗 同步化疗 客观缓解率 肿瘤标志物 不良反应 

分 类 号：R735.1[医药卫生—肿瘤]