卡络磺钠联合奥美拉唑治疗急性上消化道出血患者的效果  

Effects of Carbazochrome sodium sulfonate combined with Omeprazole in treatment of patients with acute upper gastrointestinal bleeding

作　　者：姚文琳 刘路[1] YAO Wenlin;LIU Lu(Emergency Medical Center of the First Affiliated Hospital of Shihezi University,Shihezi 832000 Xinjiang,China)

机构地区：[1]石河子大学第一附属医院急诊医学中心,新疆石河子832000

出　　处：《中国民康医学》2025年第1期41-43,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察卡络磺钠联合奥美拉唑治疗急性上消化道出血患者的效果。方法:选取2020年1月至2023年1月该院收治的100例急性上消化道出血患者进行前瞻性研究,按随机数字表法将其分为研究组与对照组各50例。对照组采用注射用奥美拉唑治疗,研究组在对照组基础上联合注射用卡络磺钠治疗,比较两组临床疗效,治疗前后血象指标、凝血功能指标[凝血酶原时间(PT)、D-二聚体(D-D)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)]水平,以及不良反应发生率。结果:研究组治疗总有效率为98.00%,高于对照组的84.00%,差异有统计学意义(P<0.05);两组红细胞计数、血小板计数、血红蛋白水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组D-D、APTT、PT水平均低于治疗前,且研究组低于对照组,两组FIB水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:卡络磺钠联合奥美拉唑治疗急性上消化道出血患者可提高治疗总有效率和血象指标水平,以及改善凝血功能指标水平的效果优于单纯奥美拉唑治疗。Objective:To observe effects of Carbazochrome sodium sulfonate combined with Omeprazole in treatment of patients with acute upper gastrointestinal bleeding.Methods:A prospective study was conducted on 100 patients with acute upper gastrointestinal bleeding admitted to this hospital from January 2020 to January 2023.According to the random number table method,they were divided into study group and control group,50 cases in each group.The control group was treated with Omeprazole for injection,while the study group was treated with Carbazochrome sodium sulfonate for injection on the basis of that of the control group.The clinical efficacy,the levels of hemogram indexes and coagulation function indexes[prothrombin time(PT),D-dimer(D-D),activated partial thromboplastin time(APTT),fibrinogen(FIB)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 98.00%,which was higher than 84.00%in the control group,and the difference was statistically significant(P<0.05).The red blood cell counts,the platelet counts and the hemoglobin levels of the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of D-D,APTT and PT in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the FIB levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Carbazochrome sodium sulfonate combined with Omeprazole in the treatment of the patients with acute upper gastrointestinal bleeding can improve the total effective rate of treatment and the levels of

关 键 词：急性上消化道出血 卡络磺钠 奥美拉唑 血象 凝血功能 不良反应 

分 类 号：R573.2[医药卫生—消化系统]