化痰通络汤联合依达拉奉右莰醇注射用浓溶液治疗急性缺血性卒中患者的效果  

Effects of Huatan Tongluo decoction combined with Edaravone Dexmedetomidine Injection Concentrated Solution in treatment of patients with acute ischemic stroke

作　　者：赵永攀 ZHAO Yongpan(Department of Encephalopathy of Biyang County Hospital of Traditional Chinese Medicine,Zhumadian 463700 Henan,China)

机构地区：[1]泌阳县中医院脑病科,河南驻马店463700

出　　处：《中国民康医学》2025年第1期96-98,105,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察化痰通络汤联合依达拉奉右莰醇注射用浓溶液治疗急性缺血性卒中患者的效果。方法:回顾性分析2022年9月至2023年9月该院收治的82例急性缺血性卒中患者的临床资料,按照治疗方法不同将其分为研究组和对照组各41例。两组均予以基础治疗,在此基础上,对照组采用依达拉奉右莰醇注射用浓溶液治疗,研究组在对照组基础上联合化痰通络汤治疗,两组均连续治疗28 d。比较两组临床疗效,治疗前后神经功能[美国国立卫生研究院卒中量表(NIHSS)、改良Rankin量表(MRS)]评分、中枢神经特异性蛋白(S100β)水平、血管内皮功能指标[内皮素-1(ET-1)、一氧化氮(NO)]水平,以及不良反应发生率。结果:研究组治疗总有效率为95.12%(39/41),高于对照组的75.61%(31/41),差异有统计学意义(P<0.05);治疗后,两组NIHSS、MRS评分和S100β水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组NO水平均高于治疗前,且研究组高于对照组,两组ET-1水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:化痰通络汤联合依达拉奉右莰醇注射用浓溶液治疗急性缺血性卒中患者可提高治疗总有效率,降低神经功能评分和S100β水平,改善血管内皮功能指标水平,效果优于单纯依达拉奉右莰醇注射用浓溶液治疗。Objective:To observe effects of Huatan Tongluo decoction combined with Edaravone Dexmedetomidine Injection Concentrated Solution in treatment of patients with acute ischemic stroke.Methods:The clinical data of 82 patients with acute ischemic stroke admitted to this hospital from September 2022 to September 2023 were retrospectively analyzed.According to different treatment methods,they were divided into study group and control group,41 cases in each group.Both groups were given basic treatment.On this basis,the control group was treated with Edaravone Dexmedetomidine Injection Concentrated Solution,while the study group was treated with Huatan Tongluo decoction on the basis of that of the control group.Both groups were treated for 28 d.The clinical efficacy,the neurological function[National Institutes of Health stroke scale(NIHSS),modified Rankin scale(MRS)]score,the central nervous specific protein(S100β)level,the vascular endothelial function index[endothelin-1(ET-1),nitric oxide(NO)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 95.12%(39/41),which was higher than 75.61%(31/41)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS and MRS scores and the S100βlevels in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of NO in the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the levels of ET-1 in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conc

关 键 词：急性缺血性卒中 化痰通络汤 依达拉奉右莰醇注射用浓溶液 神经功能 血管内皮功能 不良反应 

分 类 号：R743.3[医药卫生—神经病学与精神病学]