脑血康联合阿司匹林治疗老年腔隙性脑梗死患者的效果  

Effects of Naoxuekang combined with Aspirin in treatment of elderly patients with lacunar cerebral infarction

作　　者：张荣阁 赵向东 ZHANG Rongge;ZHAO Xiangdong(Third Department of Geriatrics of Yangpu Hospital Affiliated to Tongji University,Shanghai 200090,China)

机构地区：[1]同济大学附属杨浦医院老年三科,上海200090

出　　处：《中国民康医学》2025年第1期102-105,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察脑血康联合阿司匹林治疗老年腔隙性脑梗死患者的效果。方法:选取2020年1月至2023年12月该院收治的82例老年腔隙性脑梗死患者进行前瞻性研究,按随机数字表法将其分为对照组(n=41)和研究组(n=41)。对照组采用阿司匹林治疗,研究组在对照组基础上联合脑血康治疗,比较两组临床疗效,治疗前后炎性因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)]水平、美国国立卫生研究院卒中量表(NIHSS)评分、血小板聚集率、脑血流动力学指标[平均血流速度(MFV)、脑血流量(CBF)]水平,以及不良反应发生率。结果:研究组治疗总有效率为90.24%(37/41),高于对照组的73.17%(30/41),差异有统计学意义(P<0.05);治疗后,研究组IL-6、CRP水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组NIHSS评分和血小板聚集率均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组MFV、CBF均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:脑血康联合阿司匹林治疗老年腔隙性脑梗死患者可提高治疗总有效率和脑血流动力学指标水平,降低炎性因子水平、NIHSS评分和血小板聚集率,效果优于单纯阿司匹林治疗。Objective:To observe effects of Naoxuekang combined with Aspirin in treatment of elderly patients with lacunar cerebral infarction.Methods:A prospective study was conducted on 82 elderly patients with lacunar cerebral infarction admitted to this hospital from January 2020 to December 2023.According to the random number table method,they were divided into control group(n=41)and study group(n=41).The control group was treated with Aspirin,while the study group was treated with Naoxuekang on the basis of that of the control group.The clinical efficacy,the levels of inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP)],the National Institutes of Health stroke scale(NIHSS)score,the platelet aggregation rate,the cerebral hemodynamic indexes[mean cerebral blood flow velocity(MFV),cerebral blood flow(CBF)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 90.24%(37/41),which was higher than 73.17%(30/41)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of IL-6 and CRP in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the NIHSS score and the platelet aggregation rate in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the MFV and CBF in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Naoxuekang combined with Aspirin in the treatment of the elderly patients with lacunar cerebral infarction can improve the total effective rate of treatment and the levels of cerebral hemodynamics,and reduce the levels of inflammatory factors,the NIHSS scores and the platelet aggregation

关 键 词：老年 腔隙性脑梗死 脑血康 阿司匹林 脑血流动力学 炎性因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]