泮托拉唑与奥美拉唑联合奥曲肽治疗消化性溃疡合并上消化道出血患者的效果比较  

Comparison of effects of Pantoprazole and Omeprazole combined with Octreotide in treatment of patients with peptic ulcer complicated with upper gastrointestinal bleeding

作　　者：张培培 吕冰冰[2] ZHANG Peipei;LYU Bingbing(Anqiu People’s Hospital Department of Digestive Medicine,Anqiu 262100 Shandong,China;Anqiu People’s Hospital Department of Radiotherapy,Anqiu 262100 Shandong,China)

机构地区：[1]安丘市人民医院消化内科,山东安丘262100 [2]安丘市人民医院放疗科,山东安丘262100

出　　处：《中国民康医学》2025年第1期144-147,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较泮托拉唑与奥美拉唑联合奥曲肽治疗消化性溃疡合并上消化道出血患者的效果。方法:选取2021—2022年该院收治的220例消化性溃疡合并上消化道出血患者进行前瞻性研究,按照随机数字表法将其分为研究组与对照组各110例。对照组采用奥美拉唑联合奥曲肽治疗,研究组采用泮托拉唑联合奥曲肽治疗,比较两组临床疗效、住院时间,治疗前后凝血功能指标[活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)]、血清炎性因子[白细胞介素(IL)-17、IL-6]、血清氧化应激指标[丙二醛、抗利尿激素(ADH)]水平,以及不良反应发生率。结果:研究组治疗总有效率为97.27%,高于对照组的90.00%,差异有统计学意义(P<0.05);研究组住院时间明显短于对照组,差异有统计学意义(P<0.05);治疗后,两组TT、APTT、PT均短于治疗前,且研究组短于对照组,差异有统计学意义(P<0.05);治疗后,两组血清IL-6、IL-17等炎性因子水平和丙二醛、ADH等氧化应激指标水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为5.45%,明显低于对照组的13.64%,差异有统计学意义(P<0.05)。结论:泮托拉唑联合奥曲肽治疗消化性溃疡合并上消化道出血患者可提高治疗总有效率,缩短住院时间、TT、APTT、PT,降低炎性因子水平、氧化应激指标水平和不良反应发生率,效果优于奥美拉唑联合奥曲肽治疗。Objective:To compare effects of Pantoprazole and Omeprazole combined with Octreotide in treatment of patients with peptic ulcer complicated with upper gastrointestinal bleeding.Methods:A prospective study was conducted on 220 patients with peptic ulcer complicated with upper gastrointestinal bleeding admitted to this hospital from 2021 to 2022.According to the random number table method,they were divided into study group and control group,110 cases in each group.The control group was treated with Omeprazole combined with Octreotide,while the study group was treated with Pantoprazole combined with Octreotide.The clinical efficacy,the hospitalization time,the coagulation function indexes[activated partial thromboplastin time(APTT),thrombin time(TT),prothrombin time(PT)]levels,the serum inflammatory factors[interleukin(IL)-17,IL-6]levels,the serum oxidative stress indexes[malondialdehyde,antidiuretic hormone(ADH)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 97.27%,which was significantly higher than 90.00%in the control group,and the difference was statistically significant(P<0.05).The hospitalization time of the study group was significantly shorter than that of the control group,and the difference was statistically significant(P<0.05).After the treatment,the TT,APTT and PT in the two groups were shorter than those before the treatment,those in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of inflammatory factors such as IL-6 and IL-17 and oxidative stress indexes such as malondialdehyde and ADH in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the study group was 5.45%,which was significantly lo

关 键 词：消化性溃疡 上消化道出血 泮托拉唑 奥美拉唑 奥曲肽 氧化应激 

分 类 号：R573.2[医药卫生—消化系统]