大黄复方保留灌肠治疗继发性胃肠功能障碍疗效的Meta分析  

Meta-analysis of the Efficacy of Rhubarb Compound Retention Enema in Treating Secondary Gastrointestinal Dysfunction

作　　者：闫婷 史英[2] 杨薪博[2] 刘金响 马小兵[2] 刘新阳 刘旭雯 Yan Ting;Shi Ying;Yang Xinbo;Liu Jinxiang;Ma Xiaobing;Liu Xinyang;Liu Xuwen(Shaanxi University of Chinese Medicine,Shaanxi,Xi′an 712046,China;不详)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西中医药大学第二附属医院,陕西咸阳712000

出　　处：《中国中医急症》2024年第12期2074-2081,共8页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金青年项目(82104396);陕西省科技厅青年项目(S2024-JC-QN-2019);陕西省科技厅青年项目(2022JM-506);陕西中医药大学校级科研课题国家基金培育类项目一般项目(2021GP44)。

摘　　要：目的评价大黄复方保留灌肠治疗继发性胃肠功能障碍的疗效。方法通过计算机检索中国知网(CNKI)、万方医学(WF)、中文科技期刊数据库(VIP)、中国生物医学(CBM)、PubMed、EMbase、Cochrane Library,检索数据库时限为建库至2024年6月20日,依据纳排标准筛选文献,运用Cochrane偏倚风险评估工具评价纳入文献质量,采用Revman5.4进行Meta分析。结果共纳入15项随机对照研究、688例患者,结果显示,与西医常规治疗相比,在临床总有效率、胃肠功能障碍评分、急性生理与慢性健康量表(APACHEⅡ)评分、中医证候评分、肠鸣音恢复时间、首次排气时间、首次排便时间、腹痛、腹胀缓解时间、C反应蛋白(CRP)水平、降钙素原(PCT)水平、白细胞计数(WBC)水平、肿瘤坏死因子-α(TNF-α)水平、白细胞介素-6(IL-6)水平、D-乳酸(D-Lac)、胺氧化酶(DAO)、腹内压(IAP)、血清胃动素(MTL)、28 d病死率、多器官功能障碍综合征(MODS)发生率方面,含传统中药大黄复方保留灌肠能更加有效地治疗继发性胃肠功能障碍。结论采用大黄复方保留灌肠可有效提高治疗继发性胃肠功能障碍临床疗效。Objective:To evaluate the efficacy of rhubarb compound retention enema in treating secondary gas⁃trointestinal dysfunction.Methods:A computer search was conducted on databases including China National Knowledge Infrastructure(CNKI),Wanfang Medical Network(WF),VIP Information(VIP),China Biology Medi⁃cine disc(CBM),PubMed,EMbase,and Cochrane Library from inception to June 20,2024.Literature was selected based on inclusion and exclusion criteria,and the quality of included studies was assessed using the Cochrane risk of bias assessment tool.Meta-analysis was performed using Revman5.4.Results:Fifteen randomized controlled tri⁃als involving 688 patients were included.The results showed that compared with conventional western medicine treatment,rhubarb compound retention enema significantly improved overall clinical efficacy,gastrointestinal dys⁃function score,APACHEⅡscore,TCM syndrome score,recovery time of bowel sounds,first flatus time,first defeca⁃tion time,relief time of abdominal pain and distension,levels of C-reactive protein(CRP),procalcitonin(PCT),white blood cell count(WBC),tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),D-lactate(D-Lac),di⁃amine oxidase(DAO),intra-abdominal pressure(IAP),serum motilin(MTL),28 day mortality rate,and incidence of multiple organ dysfunction syndrome(MODS).Conclusion:The application of rhubarb compound retention ene⁃ma can effectively improve the overall clinical efficacy and has good clinical outcomes in treating secondary gastro⁃intestinal dysfunction.

关 键 词：胃肠功能障碍 大黄复方 保留灌肠 继发性 META分析 

分 类 号：R573[医药卫生—消化系统]