Epigenetics in high-altitude adaptation and disease  

表观遗传在高海拔适应性及相关疾病中的作用

作　　者：Siyang Wang Quan Hong Ying Zheng Shuwei Duan Guangyan Cai Xiangmei Chen 王思扬;洪权;郑颖;段姝伟;蔡广研;陈香美

机构地区：[1]Department of Nephrology,the First Medical Centre,Chinese PLA General Hospital,Chinese PLA Institute of Nephrology,State Key Laboratory of Kidney Diseases,National Clinical Research Center for Kidney Diseases,Beijing 100853,China [2]Department of Emergency Medicine,Xinqiao Hospital,Army Medical University(Third Military Medical University),Chongqing 400037,China

出　　处：《Science Bulletin》2024年第24期3806-3811,共6页科学通报(英文版)

基　　金：supported by the National Natural Science Foundation of China(No.82200762);the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(No.GZC20242289);research grants from the Natural Foundation of Shigatse.

摘　　要：Hypobaric and hypoxic conditions in high-altitude areas have adverse effects on the respiratory system,circulatory system,and nervous system,and these effects have unique impacts on human health and survival.Owing to the geography and climate of these regions,long-term residents face a variety of health challenges.High-altitude hypoxia can cause symptoms of altitude sickness,such as insomnia,headache,nausea and dyspnea,and in severe cases,high altitude pulmonary edema or high altitude cerebral edema.Human populations that have inhabited high-altitude envi-ronments for thousands of years,including Andeans.

关 键 词：ALTITUDE EDEMA RESPIRATORY 

分 类 号：R363[医药卫生—病理学]