基于数据挖掘技术探讨《温病条辨》与《伤寒论》用药传承关系  

Exploration of the Relationship Between Medication Inheritance in Wen Bing Tiao Bian and Shang Han Lun Based on Data Mining Techniques

作　　者：王桐 夏淑洁 王洋[1,2,3] 米丽芬 沈姗怡[1,2,3] 江铭倩 李灿东 WANG Tong;XIA Shujie;WANG Yang;MI Lifen;SHEN Shanyi;JIANG Mingqian;LI Candong(Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Fujian Key Laboratory of Traditional Chinese Medicine Health State,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Collaborative Innovation Center of Health Management of Traditional Chinese Medicine of Fujian Province in 2011,Fuzhou 350122,China;Affiliated People's Hospital,Fujian University of Traditional Chinese Medicine,Fuzhou 350000,China)

机构地区：[1]福建中医药大学,福州350122 [2]福建省中医健康状态辨识重点实验室,福州350122 [3]福建省2011中医健康管理协同创新中心,福州350122 [4]福建中医药大学附属人民医院,福州350000

出　　处：《中国中医基础医学杂志》2025年第1期60-64,共5页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金项目(82204977);福建中医药大学青年科技创新培育项目(XQC2023002)。

摘　　要：目的通过《伤寒论》《温病条辨》中所用方药分析二者之间在用药方面的传承关系。方法选用《伤寒论》及《温病条辨》上、中、下三焦篇中所用方剂,建立方药数据库,运用Excel 2021、SPSS Modeler 18.0以及Lantern 5.0软件对药物进行频次、关联规则及隐结构分析,比较《温病条辨》与《伤寒论》之间用药规律的联系与区别。结果纳入方剂310首(《伤寒论》110首,《温病条辨》200首),涉及中药255味(《伤寒论》77味,《温病条辨》251味),总累计频次1861次。用药频次≥30的药物除了常用药甘草、生姜、大枣外,《伤寒论》中依次为桂枝、白芍;《温病条辨》中依次为人参、茯苓、白芍、麦冬、半夏、地黄;两书中用药合并分析依次为白芍、桂枝、人参、半夏、茯苓、干姜、黄芩、附子、黄连、麦冬、厚朴、苦杏仁、大黄、地黄。关联规则分析得到《伤寒论》《温病条辨》有效关联规则分别为41、25条,对两书方剂合并后再分析得到有效关联规则131条。隐结构分析得到《伤寒论》《温病条辨》隐变量分别为4、10个,合并分析得到隐变量12个,隐类均为2个对隐变量进行综合聚类后,得到《伤寒论》《温病条辨》核心方剂分别为4、6个,合并分析得到8个核心方剂。通过单独与合并用药分析与比较,探讨了《温病条辨》对《伤寒论》用药规律的继承与发展。结论《温病条辨》全面传承了《伤寒论》用药特点,尤其重视补虚类药物的运用,并且发展了《伤寒论》中化湿类药物的应用。Objective Through the prescription used in Shang Han Lun and Wen Bing Tiao Bian,the inheritance relationship between the two drugs was analyzed.Methods The formula database was established.Excel 2021,SPSS Modeler 18.0 and Lantern 5.0 were used to analyze the frequency,association rules and hidden structure of drugs,and compare the relationship and difference of drug use rules between Wen Bing Tiao Bian and Shang Han Lun.Results A total of 310 prescriptions were included(110 in Shang Han Lun,200 in Wen Bing Tiao Bian),involving a total of 255 drugs(77 in Shang Han Lun,251 in Wen Bing Tiao Bian),with a total cumulative frequency of 1,861.Except for licorice,ginger,and jujube in the drugs with frequency≥30 times were commonly used,cassia twig and paeony were successively used in Shang Han Lun.Ginseng,poria cocos,paeony,ophiopogonis ophiopogonis,pinellia pinellia and rehmanniae were successively included in Wen Bing Tiao Bian.Combined drug analysis was followed by paeony,cassia twig,ginseng,pinellia pinellia,poria cocos,dried ginger,scutellaria scutellaria,aconitum aconitum,radix ophiopogonicus,magnolia officinalis,bitter almond,rhubarb and rehmannia rehmanniae.The analysis of association rules showed that there were 41 and 25 effective association rules in Shang Han Lun and Wen Bing Tiao Bian,and 131 effective association rules in combined analysis.According to the analysis of Latent structure,the hidden variables of Shang Han Lun and Wen Bing Tiao Bian are respectively 4 and 10.According to the combined analysis,the hidden variables are 12.The hidden categories are all 2.Combined with the inference of professional knowledge.There were 4 and 6 core prescriptions in Shang Han Lun and Wen Bing Tiao Bian respectively,and 8 core prescriptions were obtained by joint analysis.Through drug analysis and comparison,the inheritance and development of drug use rules of Wen Bing Tiao Bian and Shang Han Lun were discussed.Conclusion Wen Bing Tiao Bian has inherited the drug use characteristics of Shang Han Lun in a comprehensi

关 键 词：《伤寒论》 《温病条辨》 方药 数据挖掘 传承 

分 类 号：R222.2[医药卫生—中医基础理论]