乌头汤及其配伍对抗类风湿性关节炎的机制  

Mechanisms of Wutou Decoction and Its Compatibility in Combating Rheumatoid Arthritis

作　　者：姜永新 刘凯丰 胡成祥 李婉南 韩葳葳[1] JIANG Yongxin;LIU Kaifeng;HU Chengxiang;LI Wannan;HAN Weiwei(Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education,Jilin University,Changchun 130012,China)

机构地区：[1]吉林大学分子酶学工程教育部重点实验室,长春130012

出　　处：《吉林大学学报(理学版)》2025年第1期191-200,共10页Journal of Jilin University:Science Edition

基　　金：国家重点研发计划项目(批准号:2021YFA1500403).

摘　　要：利用网络药理学和分子对接技术研究乌头汤配伍3种中药对抗类风湿性关节炎(RA)的机制,并通过细胞实验对通路和靶点进行验证.结果表明:PI3K-Akt信号通路和NF-κB信号通路是关键通路;AKT1,EGFR,HIF1A和NFKB1等靶标在乌头共煎汤对抗类风湿性关节炎中起重要作用.研究结果揭示了对抗RA的关键通路,阐述了乌头汤和3种中药配伍的相关机制,为传统中草药配伍机制的研究提供了一个新方向.We used network pharmacology and molecular docking technology to study the mechanism of Wutou decoction(WTD)combined with three traditional Chinese medicines in combating rheumatoid arthritis(RA),and validated the pathways and targets through cell experiment.The results show that the PI3K-Akt signaling pathway and NF-κB signaling pathway are key pathways.The targets such as AKT1,EGFR,HIF1A and NFKB1 play important roles in the anti RA effect of WTD.The research results revealed the key pathways for combating RA and elucidated the relevant mechanisms of compatibility between WTD and three traditional Chinese medicines,providing a new direction for the study of traditional Chinese herbal medicine compatibility mechanisms.

关 键 词：网络药理学 类风湿性关节炎 乌头汤 配伍 分子对接 

分 类 号：R966[医药卫生—药理学]