基于中医时间医学角度探讨生物节律对肝癌防治的影响  

Effect of biological rhythm on prevention and treatment of liver cancer based on traditional Chinese medicine time medicine

作　　者：朱弈桦 王礼宁 李晓月 李丽秋 李尚真 李沐哲 张天驰 马勇[1,2,4] 易永祥 ZHU Yihua;WANG Lining;LI Xiaoyue;LI Liqiu;LI Shangzhen;LI Muzhe;ZHANG Tianchi;MA Yong;YI Yongxiang(New Technologies of Bone Injury Repair and Reconstruction Laboratory,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210023,China;College of Integrated Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China;Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing 210037,China;Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Yancheng TCM Hospital,Yancheng 224001,China;Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine,Nanjing Drum Tower Hospital,Nanjing 210008,China)

机构地区：[1]南京中医药大学骨伤修复与重建新技术实验室,南京210023 [2]南京中医药大学中西医结合学院,南京210023 [3]南京中医药大学附属南京医院,南京210023 [4]南京中医药大学附属盐城中医院,盐城市中医院,盐城224001 [5]南京中医药大学鼓楼临床学院,南京鼓楼医院,南京210008

出　　处：《天津中医药》2025年第1期125-130,共6页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81973885);江苏高校优势学科(中西医结合)建设工程资助项目—苏政办发[2018]87号;江苏高校中西医临床医学品牌专业建设工程资助项目(二期)(2020PPZXL261);国家中医药管理局高水平中医药重点学科-中医骨伤科学。

摘　　要：中医时间医学是以“天人相应”为核心,研究自然时间节律与人体周期性生命活动间对应关系,以指导疾病预防、诊疗和预后的学科。肝癌在癌症导致的相关性死亡中高居第3位,严重危及人体健康。肝为“将军之官”,主疏泄,体阴而用阳,其功能的显著节律性与规律的饮食、劳作等生命活动息息相关。因此,紊乱的生物节律也势必对肝癌的发展和病情的恶化有着推动作用。文章从中医时间医学角度探讨肝与生物节律的相关性,具体阐述作息和饮食节律对肝脏发展的影响,并结合现代生物钟理念,探讨肝癌时间疗法的应用,希望能丰富临床对肝癌的认知并提供一些潜在的有效治疗手段。Traditional Chinese medicine time medicine is the study of the relationship between natural time rhythms and cyclical biological rhythms of the human body based on the core principle of“correspondence of human body and nature environment”,which guides the prevention,diagnosis,treatment and prognosis of diseases.Liver cancer is the third most common cause of cancer-related deaths in the world with a serious threat to human health.The liver as“official of the general”with yang for yin function governs conveyance and dispersion,and the rhythmic nature of the liver’s function is reflected in its regulation of various biological rhythms,including rest,diet and work.Therefore,the disruption of the biological rhythm inevitably plays a promoting role in the development and deterioration of liver cancer.The review discusses the correlation between liver and biological rhythm from the perspective of traditional Chinese medicine time medicine,specifies the influence of rest and diet rhythm on liver development,and discusses the application of liver cancer chronotherapy in conjunction with modern biological clock concept,hoping to enrich the clinical knowledge of liver cancer and provide some potential effective treatment options.

关 键 词：中医时间医学 肝癌 生物节律 生物钟 时间疗法 

分 类 号：R735.7[医药卫生—肿瘤]