胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ及胃泌素-17在慢性萎缩性胃炎伴肠上皮化生患者中的表达  

Expression of pepsinogenⅠ,pepsinogenⅡand gastrin-17 in patients with chronic atrophic gastritis with intestinal metaplasia

作　　者：李明莉[1] 刘泽霞 魏红[1] 刘丽娜[1] LI Mingli;LIU Zexia;WEI Hong;LIU Lina(Clinical Laboratory Department,Weifang Hospital of Traditional Chinese Medicine,Weifang 261041,China)

机构地区：[1]潍坊市中医院检验科,山东潍坊261041

出　　处：《临床医学研究与实践》2025年第1期59-62,共4页Clinical Research and Practice

基　　金：潍坊市卫生健康委员会科研项目(No.WFWSJK-2022-271)。

摘　　要：目的 探讨胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)和胃泌素-17(G-17)在慢性萎缩性胃炎(CAG)伴肠上皮化生患者中的表达。方法 选取2022年1月至12月经我院检查确诊的71例CAG未伴肠上皮化生患者作为CAG组,86例CAG伴肠上皮化生患者作为肠上皮化生组,98例慢性非萎缩性胃炎(CNAG)患者作为CNAG组。比较三组的血清学标志物水平(包括PGⅠ、PGⅡ及G-17)及不同肠上皮化生程度患者的血清学标志物水平,并采用受试者工作特征(ROC)曲线评价血清学标志物对CAG伴肠上皮化生的诊断效能。结果 CAG组和肠上皮化生组的PGⅠ水平和PGR低于CNAG组,PGⅡ及G-17水平高于CNAG组,差异具有统计学意义(P<0.05);肠上皮化生组的PGⅠ水平低于CAG组,PGⅡ及G-17水平高于CAG组,差异具有统计学意义(P<0.05)。重度肠上皮化生的PGⅠ水平低于轻度肠上皮化生,PGⅡ及G-17水平高于轻度肠上皮化生,差异具有统计学意义(P<0.05)。ROC曲线结果显示,PGⅡ和G-17的曲线下面积(AUC)分别为0.74和0.86,灵敏度和特异度均高于70.00%,其对CAG伴肠上皮化生具有较高诊断效能。结论 低水平的PGⅠ、PGR和高水平的PGⅡ、G-17提示患者有发生CAG的风险;低水平的PGⅠ和高水平的PGⅡ、G-17提示可能与CAG伴肠上皮化生的发生有关,其中高水平G-17对CAG伴肠上皮化生有更好的预测效能,可进一步为临床早期诊断CAG伴肠上皮化生提供依据。Objective To investigate the expression of pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),gastrin-17(G-17)in patients with chronic atrophic gastritis(CAG)with intestinal metaplasia.Methods From January to December 2022,71 patients with CAG without intestinal metaplasia diagnosed by our hospital were selected as CAG group,86 patients with CAG with intestinal metaplasia were selected as intestinal metaplasia group,and 98 patients with chronic non-atrophic gastritis(CNAG)were selected as CNAG group.The levels of serological markers(including PGⅠ,PGⅡ,G-17)among the three groups and patients with different degrees of intestinal metaplasia were compared.The receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of serological markers on CAG with intestinal metaplasia.Results The level of PGⅠand PGR in the CAG group and the intestinal metaplasia group were lower than those in the CNAG group,and the levels of PGⅡand G-17 were higher than those in the CNAG group(P<0.05);the level of PGⅠin the intestinal metaplasia group was lower than that in the CAG group,and the levels of PGⅡand G-17 were higher than those in the CAG group,the differences were statistically significant(P<0.05).The level of PGⅠin the severe intestinal metaplasia was lower than that in the mild intestinal metaplasia,and the levels of PGⅡand G-17 were higher than those in the mild intestinal metaplasia,the differences were statistically significant(P<0.05).The results of ROC curve showed that the area under curve(AUC)of PGⅡand G-17 were 0.74 and 0.86,respectively,and the sensitivity and specificity were higher than 70.00%,which had high diagnostic efficacy in the diagnosis of CAG with intestinal metaplasia.Conclusion Low level of PGⅠ,PGR and high levels of PGⅡ,G-17 suggest that patients have the risk of CAG;low level of PGⅠand high level of PGⅡand G-17 may be related to the occurrence of CAG with intestinal metaplasia,and high level of G-17 has a better predictive efficacy on CAG with intestinal metapl

关 键 词：慢性萎缩性胃炎 肠上皮化生 胃蛋白酶原 胃泌素-17 

分 类 号：R573.3[医药卫生—消化系统]