老年急性进展性脑梗死患者血清磷脂酶A2、S100钙结合蛋白B水平与颈动脉斑块的联系  

Elderly acute progressive cerebral infarction patients′serum PLA2,called S100B levels and the relation-ship between carotid plaques

作　　者：贾燕燕 孙翊嘉 赵迪[1] 宋彦[2] JIA Yanyan;SUN Yijia;ZHAO Di;SONG Yan(Department of Neurology,Nanyang Central Hospital,Nanyang 473000,He′nan,China;不详)

机构地区：[1]南阳市中心医院神经内科,河南南阳473000 [2]南阳市第二人民医院神经内科,河南南阳473000

出　　处：《实用医学杂志》2025年第2期244-249,共6页The Journal of Practical Medicine

基　　金：河南省医学科技攻关计划(联合共建)项目(编号:LHGJ20191467)。

摘　　要：目的探讨老年急性进展性脑梗死患者血清磷脂酶A2(PLA2)、S100钙结合蛋白B(S100B)和颈动脉斑块的关系。方法将2021年1月至2022年6月收治的120例老年急性进展性脑梗死患者纳入观察组,同期将115例非进展性脑梗死患者为非进展组,100例健康人员为健康组。将观察组分为无斑块组34例、斑块稳定组45例和斑块不稳定组41例。分析血清PLA2、S100B水平与颈动脉斑块的关系。ROC分析二者对颈动脉斑块的预测价值。随访1年,以复发和死亡为终点事件分析生存率。结果斑块稳定组、斑块不稳定组血清PLA2、S100B高于无斑块组,差异有统计学意义(P<0.05)。血清PLA2、S100B与颈动脉斑块呈正相关。ROC显示二者联合预测的价值更高(P<0.05)。结论血清PLA2、S100B在老年急性进展性脑梗死患者水平升高,与颈动脉斑块关系密切。Objective To explore the relationship between serum phospholipase A2(PLA2),S100 calcium-binding protein B(S100B)and carotid plaque in elderly patients with acute progressive cerebral infarction.Methods From January 2021 to June 2022,120 elderly patients with acute progressive cerebral infarction were enrolled in the study group,while 115 patients with non-progressive cerebral infarction were classified as non-progressive group and 100 healthy people as healthy group.The study group was divided into three groups:no plaque group(34 cases),stable plaque group(45 cases)and unstable plaque group(41 cases).To analyze the relationship between serum PLA2 and S100B levels and carotid plaque.ROC analysis of their predictive value for carotid plaque.Follow-up for 1 year,the survival rate was analyzed with recurrence and death as the end points.Results The levels of serum PLA2 and S100B in stable and unstable plaque groups were higher than those in non-plaque group,and the difference was statistically significant(P<0.05).Serum PLA2 and S100B were positively correlated with carotid plaque.ROC showed that the value of joint prediction was higher(P<0.05).Conclusion The levels of serum PLA2 and S100B are increased in elderly patients with acute progressive cerebral infarction,which is closely related to carotid plaque.

关 键 词：老年急性进展性脑梗死 磷脂酶A2 S100钙结合蛋白B 颈动脉斑块 

分 类 号：R743.3[医药卫生—神经病学与精神病学]