乳癌组织中Cath-D与突变型p53的相关性及其临床意义  

Correlation between Cath-D and mutant p53 in breast cancer tissue and their clinical significance

作　　者：姜楠 王欣 马萍 张国芬 李向利 JIANG Nan;WANG Xin;MA Ping;ZHANG Guofen;LI Xiangli(Department of Thoracic Surgery,Beijing Chest Hospital,Capital Medical University,Beijing 101149,China)

机构地区：[1]首都医科大学附属北京胸科医院胸外二科,北京101149 [2]天津医科大学肿瘤医院乳腺一科 [3]清华大学第一附属医院病理科 [4]清华大学第一附属医院普外科

出　　处：《青岛大学学报(医学版)》2024年第6期796-800,共5页Journal of Qingdao University(Medical Sciences)

基　　金：国家自然科学基金资助项目(82172835)。

摘　　要：目的探讨乳癌组织中人组织蛋白酶D(Cath-D)与突变型p53的相关性及其临床意义。方法采用免疫组化法检测156例乳癌标本中Cath-D与突变型p53蛋白的表达,分析二者的相关性以及Cath-D表达与临床病理特征的关系。结果乳癌组织中Cath-D与突变型p53的阳性表达率分别是74.4%和58.3%。与无淋巴结转移和组织学Ⅰ级相比,有淋巴结转移、组织学Ⅱ~Ⅲ级的乳癌病人癌组织中Cath-D的表达率显著增高(χ^(2)=4.416、19.896,P<0.05)。相关分析结果显示,乳癌组织中Cath-D的表达与人类表皮生长因子受体2(Her-2)、Ki-67和突变型p53的表达呈正相关(r=0.197~0.308,P<0.05)。与Cath-D(-)、突变型p53(-)以及其他类型肿瘤相比,Cath-D(+)、突变型p53(+)以及Cath-D(+)/p53(+)肿瘤无病生存期明显缩短(χ^(2)=3.924~5.973,P<0.05),而Cath-D和突变型p53表达与病人总生存期无关(P>0.05)。结论联合检测乳癌组织中Cath-D与突变型p53的表达可判断乳癌预后,对临床治疗有一定的参考价值。Objective To investigate the correlation between Cath-D and mutant p53 in breast cancer tissue and their clinical significance.Methods Immunohistochemistry was used to measure the protein expression of Cath-D and mutant p53 in 156 breast cancer specimens,and the correlation between Cath-D and mutant p53 was analyzed,as well as the association between Cath-D expression and clinicopathological features.Results The positive expression rates of Cath-D and mutant p53 in breast cancer tissue were 74.4% and 58.3%,respectively.Compared with the patients without lymph node metastasis and those with histological grade Ⅰ breast cancer,the patients with lymph node metastasis or histological grade Ⅱ-Ⅲ breast cancer had a significant increase in the expression of Cath-D in cancer tissue(χ^(2)=4.416,19.896,P<0.05).The correlation analysis showed that the expression of Cath-D in breast cancer tissue was positively correlated with the expression of Her-2,Ki-67,and mutant p53(r=0.197-0.308,P<0.05).Compared with the Cath-D(-)group,the mutant p53(-)group,and the other types of tumor,the Cath-D(+)group,the mutant p53(+)group,and the Cath-D(+)/p53(+)group had a significantly shorter disease-free survival(χ^(2)=3.924-5.973,P<0.05),while the expression of Cath-D and mutant p53 was not correlated with the overall survival of patients(P>0.05).Conclusion The combined measurement of Cath-D and mutant p53 in breast cancer tissue can be used to assess the prognosis of breast cancer,which has a certain reference value in clinical treatment.

关 键 词：乳腺肿瘤 组织蛋白酶D 基因 p53 预后 免疫组织化学 病理学 临床 

分 类 号：R737.9[医药卫生—肿瘤] R365[医药卫生—临床医学]