Sonic Hedgehog Mediates High Frequency-Dependent Deep Brain Stimulation for the Correction of Motor Deficits in a Parkinson's Disease Model  

作　　者：Hui Zhang Yujuan Su Zhongwei Qu Chunkui Zhang Shaorong Ma Xia Li Yizheng Wang 

机构地区：[1]National Clinical Research Center for Aging and Medicine,Huashan Hospital,State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200040,China [2]Laboratory of Neural Signal Transduction,Institute of Neuroscience,Chinese Academy of Sciences,Shanghai 200031,China [3]Center of Cognition and Brain Science,Beijing Institute of Basic Medical Sciences,Beijing 100850,China

出　　处：《Neuroscience Bulletin》2024年第11期1732-1738,共7页神经科学通报(英文版)

基　　金：supported by the National Natural Science Foundation of China(82201619).

摘　　要：Dear Editor,Deep brain stimulation targeting the subthalamic nucleus(STN-DBS)can relieve motor symptoms in patients with advanced Parkinson's disease(PD).The efficacy of DBS is strongly dependent on stimulus frequency,typically exceeding 100 Hz[1].However,the mechanism underlying this high-frequency dependence remains unelucidated.DBS likely acts via several,nonexclusive mechanisms,including local and network-wide electrical and neurochemical effects,modulation of oscillatory activity,synaptic plasticity,and potentially neuroprotection and neurogenesis.Nonetheless,none of these fully explains the high-frequency dependence and the rapid therapeutic action of DBS.

关 键 词：STIMULATION DEEP EXCEEDING 

分 类 号：R742.5[医药卫生—神经病学与精神病学]