Human urinary cells for functional wound healing with sweat gland restoration  

作　　者：Shuai-Fei Ji Lai-Xian Zhou Ying-Ying Li Jiang-Bing Xiang Hua-Ting Chen Yi-Qiong Liu Xiao-Bing Fu Xiao-Yan Sun 

机构地区：[1]Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department and 4th Medical Center,Chinese PLA General Hospital and PLA Medical College/PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury,Repair and Regeneration/Research Unit of Trauma Care,Tissue Repair and Regeneration,Chinese Academy of Medical Sciences,Beijing 100048,China

出　　处：《Military Medical Research》2024年第6期959-962,共4页军事医学研究(英文版)

基　　金：supported in part by the National Natural Science Foundation of China(92268206,81830064);the CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-059);the Military Medical Research Projects(145AKJ260015000X,2022-JCJQ-ZB-09600,2020-JCJQ-ZD-256-021);the Military Medical Research and Development Projects(AWS17J005,2019-126);the Specific Research Fund of the Innovation Platform for Academicians of Hainan Province(YSPTZX202317).

摘　　要：Dear Editor,The large defects of the skin caused by burns or trauma can result in disruption of the structure and function of the skin,as well as irreversible loss of skin appendages,such as sweat glands(SG).As the important modulator of temperature homeostasis,SG damage triggers heat intolerance and thermoregulatory dysfunction,which poses a considerable threat to health and quality of life[1-3].The promotion of wound healing with SG restoration remains a challenging issue.It has been reported that there are urinary epithelial cells(UECs)in human urine samples,and they may most likely originate from renal proximal tubules[4].UECs are easy to obtain from urine samples at any age,sex,or ethnic origin except for renal failure,with a cost-effective,non-invasive and simple isolation method[4].More importantly,the extensive source of clinical urine sample makes it easy for urinary cell autogenous transplantation and individualized treatment.Therefore,it is of great significance to convert UECs into urinary epithelial stem cells(UESCs)with repair ability.In this context,we design a strategy for the pharmacological conversion of UECs into UESCs,and the repair ability of UESCs in functional skin wound healing is explored.

关 键 词：Urinary cell Urinary stem cell Wound healing Sweat gland restoration 

分 类 号：R73[医药卫生—肿瘤]