Sandmeyer法合成2-溴-6-氯甲苯  

SYNTHESIS OF 2-BROMO-6-CHLOROTOLUENEBY SANDMEYER METHOD

作　　者：王博闻 南沛然 李世云 文彬 陈兴权 鲍晓军[1,2] Wang Bowen;Nan Peiran;Li Shiyun;Wen Bin;Cheng Xingquan;Bao Xiaojun(College of Chemical Engineering,Fuzhou University,Fuzhou 350000,Fujian,China;Qingyuan Innovation Laboratory,Quanzhou 362000,Fujian,China)

机构地区：[1]福州大学化工学院,福建福州350000 [2]清源创新实验室,福建泉州362000

出　　处：《精细石油化工》2025年第1期23-26,共4页Speciality Petrochemicals

基　　金：2024年泉州市第一批高层次人才创新创业项目(No.2024QZC007R)。

摘　　要：采用Sandmeyer法以3-氯-2-甲基苯胺为原料,亚硝酸钠为重氮化试剂,在低温、酸性环境下得到重氮盐,再利用铜基催化剂、不同温度的条件下分解,得到2-氯-6-溴甲苯。适宜合成条件为:以30%硫酸溶解胺,以亚硝酸钠的硫酸溶液成盐,以氢溴酸为溴源、铜粉为催化剂、在0℃分解。其中,酸用量为原料的5倍,n(3-氯-2-甲基苯胺)∶n(亚硝酸钠)∶n(铜粉)∶n(工业氢溴酸)=1∶1.2∶0.1∶1.2,2-溴-6-氯甲苯的收率可达95%。Using the Sandmeyer method with 3-chloro-2-methylaniline as the raw material and sodium nitrite as diazotization reagent,diazonium salts were obtained at low temperature and acid environment.Then,copper-based catalysts were used to decompose diazonium salts under-different temperature conditions to obtain 2-chloro-6-bromotoluene.The optimal synthesis conditions are to dissolve the amine in 30%sulfuric acid(mass fraction),form the diazonium salt with a sulfuric acid solution of sodium nitrite,use hydrobromic acid as the bromine source,copper powder as the catalyst,and decompose at 0℃.Among them,the amount of acid used is 5 times that of the raw material,n(3-Chloro-2-methylaniline)∶n(sodium nitrite)∶n(copper)∶n(industrial hydrobromic acid)=1∶1.2∶0.1∶1.2,and the yield of 2-chloro-6-bromotoluene reaches 95%.

关 键 词：Sandmeyer反应 重氮盐 亚硝酸钠 2-溴-6-氯甲苯 3-氯-2-甲基苯胺 

分 类 号：O621.3[理学—有机化学]