异甘草酸镁联合益肝灵治疗失代偿期肝硬化患者的效果分析  

Analysis of the Efficacy of Magnesium Isoglycyrrhizinate Combined with Yiganling in Patients with Decompensated Liver Cirrhosis

作　　者：张煜 ZHANG Yu(Gastroenterology Department,Nantong Ruici Hospital,Nantong 226000,China)

机构地区：[1]南通瑞慈医院消化内科,江苏南通226000

出　　处：《中国医学创新》2025年第2期64-68,共5页Medical Innovation of China

摘　　要：目的:探讨分析异甘草酸镁联合益肝灵治疗失代偿期肝硬化患者的效果。方法:回顾性选择2022年6月—2024年5月南通瑞慈医院消化内科收治的150例失代偿期肝硬化患者,依据不同治疗方法分为单一组(n=72)和联合组(n=78)。单一组采用益肝灵治疗,联合组在单一组基础上联合异甘草酸镁治疗。比较两组治疗前后肝功能指标、肝纤维化指标、炎症因子及并发症发生情况。结果:治疗后,联合组总胆红素(total bilirubin,TBIL)、碱性磷酸酶(alkaline phosphatase,ALP)、丙氨酸氨基转移酶(alanine transaminase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)均低于单一组,白蛋白(albumin,ALB)高于单一组,差异均有统计学意义(P<0.05)。治疗后,联合组Ⅲ型前胶原(procollagen typeⅢ,PCⅢ)、层粘连蛋白(laminin,LN)、Ⅳ型胶原(collagen typeⅣ,Ⅳ-Col)、透明质酸(hyaluronic acid,HA)均低于单一组,差异均有统计学意义(P<0.05)。治疗后,联合组血清白细胞介素-8(interleukin-8,IL-8)、C反应蛋白(C reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)均低于单一组,差异均有统计学意义(P<0.05)。联合组并发症总发生率低于单一组,差异有统计学意义(P<0.05)。结论:异甘草酸镁联合益肝灵可有效缓解患者炎症反应及肝纤维化情况,改善患者肝功能,安全性更高。Objective:To investigate the effect of Magnesium Isoglycyrrhizinate combined with Yiganling in the treatment of decompensated liver cirrhosis.Method:A total of 150 patients with decompensated liver cirrhosis admitted to the Gastroenterology Department of Nantong Ruici Hospital from June 2022 to May 2024 were retrospectively selected and divided into single group(n=72)and combined group(n=78)according to different treatment methods.The single group was treated with Yiganling,and the combined group was treated with Magnesium Isoglycyrrhizinate on the basis of the single group.Liver function indexes,liver fibrosis indexes,inflammatory factors before and after treatment,complications between the two groups were compared.Result:After treatment,total bilirubin(TBIL),alkaline phosphatase(ALP),alanine transaminase(ALT),aspartate aminotransferase(AST)in the combined group were lower than those in single group,and albumin(ALB)was higher than that in single group,the differences were statistically significant(P<0.05).After treatment,the procollagen typeⅢ(PCⅢ),laminin(LN),collagen typeⅣ(Ⅳ-Col)and hyaluronic acid(HA)in combined group were lower than those in single group,the differences were statistically significant(P<0.05).After treatment,serum interleukin-8(IL-8),C reactive protein(CRP),and tumor necrosis factor-α(TNF-α)in the combined group were lower than those in the single group,the differences were statistically significant(P<0.05).The total incidence of complications in combined group was lower than that in single group,the difference was statistically significant(P<0.05).Conclusion:Magnesium Isoglycyrrhizinate combined with Yiganling can effectively relieve the inflammatory response and liver fibrosis of patients,improve the liver function of patients with higher safety.

关 键 词：异甘草酸镁 益肝灵 失代偿期肝硬化 炎症因子 

分 类 号：R575.2[医药卫生—消化系统]