基于“脾散精藏意”探讨氨基酸在认知功能障碍中的作用  

Exploring the Role of Amino Acids in Cognitive Dysfunction Based on"Spleen Governs Dispersing Essence and Storing Meaning"

作　　者：李婷婷[1,2] 战丽彬 范晓凤[1,3] LI Tingting;ZHAN Libin;FAN Xiaofeng(Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China;Key Laboratory of Liaoning Province for TCM Spleen-Viscera-State Modern Research,Shenyang 110847,China)

机构地区：[1]辽宁中医药大学中医脏象理论及应用教育部重点实验室,沈阳110847 [2]辽宁中医药大学附属医院,沈阳110032 [3]辽宁省中医脾脏象现代研究重点实验室,沈阳110847

出　　处：《世界科学技术-中医药现代化》2024年第10期2662-2667,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会重点项目(81730111):基于肠道菌群“从脾论治”疾病易感痰湿体质的中医治未病的生物学基础研究,负责人:战丽彬;国家中医药管理局国家中医药领军人才岐黄学者支持项目(国中医药人教函[2022]6号),负责人:战丽彬;中国博士后科学基金第74批面上资助(2023MD744221):基于“苹果酸-天冬氨酸穿梭”途径介导的线粒体能量代谢探究从脾论治糖尿病认知功能障碍的作用机制,负责人:李婷婷。

摘　　要：认知功能障碍归属中医学“呆病”“痴证”范畴,发病率逐年升高,调节氨基酸代谢可能是从脾论治认知功能障碍的重要机制。氨基酸为脾所散之精,布周身而司藏意,可作为潜在的生物标志物;氨基酸类神经递质散于脑,传达脾所藏之意,参与神经元通信及认知活动过程。治法以补脾益气、温阳健脾、滋阴补脾为主,兼以化痰祛瘀解毒,以调节氨基酸代谢,恢复脾主运化功能,改善认知功能障碍。在“脾散精藏意”理论指导下调节氨基酸代谢为中医药治疗认知功能障碍疾病提供了新的理论依据及研究策略。Cognitive impairment belongs to the categories of"foolish disease"and"delusional syndrome"in traditional Chinese medicine,the incidence rate is increasing year by year,and regulating amino acid metabolism may be an important mechanism for the treatment of cognitive dysfunction from the spleen.Amino acids are the essence dispersed by the spleen,which can be used as potential biomarkers.Amino acid neurotransmitters are scattered in the brain,convey the meaning of the spleen,and participate in neuronal communication and cognitive activities.The treatment method is mainly to nourish the spleen and invigorate qi,warm yang and strengthen the spleen,nourish yin and nourish the spleen,and also dissolve phlegm,dispel stasis and detoxify,so as to regulate amino acid metabolism,restore the main function of the spleen,and improve cognitive dysfunction.Under the guidance of the theory of"spleen governs dispersing essence and storing meaning",the regulation of amino acid metabolism provides a new theoretical basis and research strategy for the treatment of cognitive dysfunction diseases in traditional Chinese medicine.

关 键 词：脾散精藏意 氨基酸 认知功能障碍 从脾论治 

分 类 号：R277.7[医药卫生—中医学]