PEDF在卵巢癌中的调节机制  

Regulation Mechanism of PEDF in Ovarian Cancer

作　　者：焦晓路 JIAO Xiaolu(Department of Gynaecology,Juancheng County People's Hospital,Juancheng 274699,China)

机构地区：[1]鄄城县人民医院妇科,山东鄄城274699

出　　处：《中国医学创新》2025年第3期185-188,共4页Medical Innovation of China

摘　　要：超过2/3的卵巢癌(ovarian cancer,OC)患者确诊时已为晚期,而目前的治疗手段效果欠佳,患者预后差。近年来,分子靶向治疗在OC的治疗中占据举足轻重的地位,因此,找寻特异性细胞分子十分必要。色素上皮衍生因子(PEDF)是一种重要的抗肿瘤因子,能够通过调节磷脂酰肌醇3激酶/蛋白激酶B(PI3K/AKT)和Fas/FasL这两条通路阻断促有丝分裂信号,从而抑制肿瘤细胞的增殖及扩散。本文着重研究PEDF在OC中的调节机制,为其进一步的研究及临床应用提供参考。More than two-thirds of patients with ovarian cancer(OC)are in advanced stage when they are diagnosed.However,the current treatment methods are not effective and the prognosis of patients is poor.In recent years,molecular targeted therapy plays an important role in the treatment of OC,so it is necessary to find specific cell molecules.Pigment epithelium derivative factor(PEDF)is an important anti-tumor factor,which can block the pro-mitosis signal by regulating the phosphoinositide 3-kinase/protein kinase B(PI3K/Akt)and FAS/FASL pathways,thus inhibiting the proliferation and spread of tumor cells.This study focuses on the regulatory mechanism of PEDF in OC,so as to provide reference for its further research and clinical application.

关 键 词：卵巢癌 色素上皮衍生因子 磷脂酰肌醇3激酶/蛋白激酶B FAS/FASL 

分 类 号：R737.31[医药卫生—肿瘤]