颅内静脉窦血栓形成并发早发性癫痫的相关危险因素分析  

Analysis of relevant risk factors for early-onset epilepsy in patients with cerebral venous sinus thrombosis

作　　者：付霄霞 廖磊[2] FU Xiaoxia;LIAO Lei(Department of Neurology,Nanyang Second People's Hospital,Nanyang(473000),Henan,China)

机构地区：[1]南阳市第二人民医院神经内科,河南南阳473000 [2]南阳市第二人民医院神经介入科,河南南阳473000

出　　处：《癫痫与神经电生理学杂志》2024年第6期351-356,共6页Journal of Epileptology and Electroneurophysiology

摘　　要：目的回顾性分析颅内静脉窦血栓形成(CVST)患者并发早发性癫痫的相关影响因素。方法选取2022年1月至2023年12月南阳市第二人民医院接收的109例CVST患者作为研究对象,根据病历系统记录中患者是否合并癫痫分为早发性癫痫组和未发生癫痫组,收集并比较两组患者的临床资料,将有统计学意义的指标纳入logistic回归分析,确定CVST患者并发早发性癫痫的危险因素。结果109例CVST患者中,28例患者并发早发性癫痫,占比25.69%。两组患者的脑电图异常、妊娠/产褥期、颅内出血、多脑叶病变及偏瘫情况比较,差异有统计学意义(P<0.05)。经logistic回归分析结果发现,脑电图异常(OR=4.250,95%CI为1.667~10.834)、妊娠/产褥期(OR=3.944,95%CI为1.426~10.914)、颅内出血(OR=5.176,95%CI为1.853~14.461)、多脑叶病变(OR=4.062,95%CI为1.618~10.203)及偏瘫(OR=5.067,95%CI为1.459~17.600)均为CVST患者并发早发性癫痫的危险因素。结论脑电图异常、妊娠/产褥期、颅内出血、多脑叶病变及偏瘫为CVST患者发生早发性癫痫的独立危险因素,通过分析上述危险因素能够为临床CVST术前筛查可能并发早发性癫痫的高危群体并采取相关措施提供理论参考依据。Objective To analyze retrospectively the relevant influencing factors for early-onset epilepsy in patients with cerebral venous sinus thrombosis(CVST).Method A total of 109 patients with CVST admitted to Nanyang Second People's Hospital from January 2022 to December 2023 were selected as research subjects.The patients were divided into early-onset epilepsy and non-onset epilepsy groups according to whether they had concurrent epilepsy in the medical record system.Clinical data of two groups were collected and compared.The indexes with statistical significance were included for logistic regression analysis to determine risk factors for early onset epilepsy in the patients with CVST.Result Among 109 patients with CVST,28 patients had early-onset epilepsy,accounting for 25.69%.There were statistically significant differences in abnormal electroencephalogram(EEG),pregnancy/puerperal period,intracranial hemorrhage,multiple lobular lesions and hemiplegia between two groups(P<0.05).Logistic regression analysis showed that abnormal EEG(OR=4.250,95%CI:1.667~10.834),pregnancy/puerperal period(OR=3.944,95%CI:1.426~10.914),intracranial hemorrhage(OR=5.176,95%CI:1.853~14.461),multiple lobular lesions(OR=4.062,95%CI:1.618~10.203)and hemiplegia(OR=5.067,95%CI:1.459~17.600)were all risk factors for early-onset epilepsy in the patients with CVST.Conclusion Abnormal EEG,pregnancy/puerperal period,intracranial hemorrhage,multiple lobular lesions and hemiplegia are independent risk factors for the occurrence of early-onset epilepsy in the patients with CVST.By analyzing the above risk factors,theoretical reference can be provided for preoperative screening of high-risk population for possible concurrent early-onset epilepsy in clinical CVST and taking relevant measures.

关 键 词：颅内静脉窦血栓形成 早发性癫痫 危险因素 颅内出血 

分 类 号：R74[医药卫生—神经病学与精神病学]