利妥昔单抗,来那度胺联合奥布替尼方案治疗老年弥漫大B细胞淋巴瘤的临床观察  

Clinical Observation of Rituximab,Lenalidomide Combined with Obutinib in the Treatment of Elderly Patients with Diffuse Large B-cell Lymphoma

作　　者：郎涛[1] 李雪国 王如民 徐艳芳 古再丽努尔·吾甫尔[1] LANG Tao;LI Xue-guo;WANG Ru-min;XU Yan-fang;Guzailinuer·wufuer(Department of Hematology,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang,830001,China)

机构地区：[1]新疆维吾尔自治区人民医院血液病科,新疆乌鲁木齐830001

出　　处：《现代生物医学进展》2024年第24期4692-4694,共3页Progress in Modern Biomedicine

基　　金：新疆维吾尔自治区自然科学基金项目(2020D01C093)。

摘　　要：目的:探讨利妥昔单抗,来那度胺联合奥布替尼方案治疗老年弥漫大B细胞淋巴瘤的临床效果。方法:选取2020.5-2022.6收治的60例老年弥漫大B细胞淋巴瘤患者,分为对照组、观察组,各30例。对照组接受R-mini-CHOP方案化疗,观察组接受利妥昔单抗,来那度胺联合奥布替尼方案,比较两组相关指标。结果:观察组患者客观缓解率比对照组更高(P<0.05);观察组治疗后CD3^(+)、CD4^(+)水平比对照组更高,CD8^(+)水平比对照组更低(P<0.05);观察组治疗期间毒副反应总发生率比对照组低(P<0.05)。两组中位PFS分别为14.9周(95%CI 12~17)和5.8周(95%CI 4~7)(P<0001),两组中位OS分别为20.1周(95%CI 16~22)和7.5周(95%CI 5~9)(P<0001)。结论:利妥昔单抗、来那度胺联合奥布替尼治疗可减轻老年弥漫大B细胞淋巴瘤患者免疫损伤,存在一定安全性,临床疗效显著。Objective:To investigate the clinical effect of rituximab,lenalidomide combined with aubutinib in the treatment of elderly patients with diffuse large B-cell lymphoma.Methods:Sixty elderly patients with diffuse large B cell lymphoma admitted to2020.5-2022.6 were divided into control group and observation group,with 30 patients each.The control group received chemotherapy with R-mini-CHOP regimen,and the observation group received rituximab,lenalidomide combined with obutinib regimen,to compare the relevant indicators between the two groups.Results:Patients in the observation group had higher rates of objective response than the control group(P<0.05);they had higher CD3^(+)and CD4^(+)levels,and lower CD8^(+)levels than the control group(P<0.05);the overall incidence of toxic effects during treatment was lower than in the control group(P<0.05).The median PFS was 14.9(95%CI 12-17)and 5.8(95%CI 4-7)(P<0001),and the median OS was 20.1(95%CI 16-22)and 7.5(95%CI 5-9)(P<0001).Conclusion:Treatment with rituximab and lenalidomide combined with obutinib can reduce the immune damage in elderly patients with diffuse large B cell lymphoma,with a certain safety profile and significant clinical efficacy.Download(CAJ format)Download(PDF format)

关 键 词：弥漫大B细胞淋巴瘤 老年 利妥昔单抗 来那度胺 奥布替尼 

分 类 号：R733[医药卫生—肿瘤]