培元抗癌汤联合多西他赛与顺铂化疗方案对晚期肺癌患者免疫功能及中医证候的影响  

Effect of Peiyuan Kangai decoction combined with docetaxel and cisplatin chemotherapy on immune function and Traditional Chinese Medicine syndrome of patients with advanced lung cancer

作　　者：王慧慧 崔小婕 WANG Huihui;CUI Xiaojie(Tumor Center,The 970th Hospital of the Joint Support Force of the Chinese People's Liberation Army,Yantai,Shandong,264002,China)

机构地区：[1]中国人民解放军联勤保障部队第九七〇医院肿瘤中心,山东烟台264002

出　　处：《当代医学》2024年第21期20-23,共4页Contemporary Medicine

摘　　要：目的探讨培元抗癌汤联合多西他赛+顺铂(docetaxel+cisplatin,DP)化疗方案在晚期肺癌患者中的疗效。方法选取2020年3月至2021年12月中国人民解放军联勤保障部队第九七〇医院收治的86例晚期肺癌患者作为研究对象,采用随机数字表法分为观察组与对照组,每组43例。对照组采用DP化疗方案治疗,观察组在对照组基础上联合培元抗癌汤治疗。比较两组临床疗效及治疗前后免疫功能指标(CD3^(+)、CD4^(+)、CD8^(+))、中医证候积分、血清肿瘤标志物[癌胚抗原(carcinoembryonic antigen,CEA)及糖类抗原125(carbohydrate antigen 125,CA125)]和不良反应发生情况。结果观察组治疗总有效率为93.02%,高于对照组的76.74%,差异有统计学意义(P<0.05)。治疗后,两组CD8^(+)、CD3^(+)、CD4^(+)水平均低于治疗前,但观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组咳嗽咳痰、气喘气促、痰中带血、胸胁胀满、体倦神疲积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组CEA、CA125水平均低于治疗前,且观察组低于对照组,差异有统计学意(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论培元抗癌汤联合DP化疗方案在晚期肺癌患者中疗效显著,可改善其免疫功能,缓解临床症状,抑制肿瘤生长,且不良反应较少,值得临床推广应用。Objective To investigate the efficacy of Peiyuan Kangai decoction combined with docetaxel+cisplatin(DP)chemotherapy in pa-tients with advanced lung cancer.Methods A total of 86 patients with advanced lung cancer admitted to The 970th Hospital of the Joint Support Force of the Chinese People's Liberation Army from March 2020 to December 2021 were selected as the study subjects,and they were divided into the observation group and the control group according to the random number table method,with 43 cases in each group.The control group was treat-ed with DP chemotherapy,and the observation group was treated with Peiyuan Kangai decoction on the basis of the control group.The clinical effica-cy,immune function indexes(CD3^(+),CD4^(+),CD8^(+)),Traditional Chinese Medicine(TCM)syndrome scores,serum tumor markers(carcinoembryonic antigen[CEA]and carbohydrate antigen 125[CA125])before and after treatment,and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 93.02%,which was higher than 76.74%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CD8^(+),CD3^(+)and CD4^(+)of the two groups were lower than before treat-ment,but the observation group was higher than the control group,and the differences were statistically significant(P<0.05).After treatment,the scores for cough and sputum,wheezing and shortness of breath,bloody sputum,chest and rib distension and physical fatigue and exhaustion of the two groups were lower than before treatment,and the observation group was lower than the control group,and the differences were statistically sig-nificant(P<0.05).After treatment,the levels of CEA and CA125 of the two groups were lower than before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference w

关 键 词：晚期肺癌 培元抗癌汤 多西他赛+顺铂化疗方案 免疫功能 中医证候 不良反应 

分 类 号：R73[医药卫生—肿瘤]