Harnessing multi-omics approaches to elucidate the role of Chinese herbal compounds in chemotherapy-induced gastrointestinal damage  

作　　者：Chang Qiao Hao-Xiang Zhang Xiao-Tong Tian Yan-Jing Zhang De-Hui Li 

机构地区：[1]Graduate School,Hebei University of Chinese Medicine,Shijiazhuang 050000,Hebei Province,China [2]Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China [3]Department of Oncology I,The First Affiliated Hospital of Hebei University of Chinese Medicine(Hebei Province Hospital of Chinese Medicine),Shijiazhuang 050000,Hebei Province,China [4]Department of Oncology II,The First Affiliated Hospital of Hebei University of Chinese Medicine(Hebei Province Hospital of Chinese Medicine),Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research,Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation,Shijiazhuang 050000,Hebei Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2025年第2期35-40,共6页世界胃肠肿瘤学杂志(英文)

基　　金：Supported by 2023 Government-funded Project of the Outstanding Talents Training Program in Clinical Medicine,No.ZF2023165;Key Research and Development Projects of Hebei Province,No.18277731D;Natural Science Foundation of Hebei Province,No.H202423105.

摘　　要：In this editorial,we discuss the findings reported by Wang et al in the latest issue of the World Journal of Gastrointestinal Oncology.Various research methodologies,including microbiome analysis,assert that the Tzu-Chi Cancer-Antagonizing and Life-Protecting II Decoction of Chinese herbal compounds mitigates inflammatory responses by inhibiting the NF-κB signaling pathway.This action helps maintain the dynamic equilibrium of the intestinal microecology and lessens chemotherapy-induced gastrointestinal damage.The efficacy of these compounds is intimately linked to the composition of intestinal microbes.These compounds regulate intestinal microecology by virtue of their specific compatibility and effectiveness,thereby enhancing the overall therapeutic outcomes of cancer chemotherapy.Nonetheless,the exact mechanisms underlying these effects warrant further investigation.Multi-omics technologies offer a systematic approach to elucidate the mechanisms and effectiveness of Chinese herbal compounds in vivo.This manuscript reviews the application of multi-omics technologies to Chinese herbal compounds and explores their potential role in modulating the gastrointestinal microenvironment following cancer chemotherapy,thus providing a theoretical foundation for their continued use in adjunct cancer treatment.

关 键 词：Chinese herbal compounds Gastrointestinal microenvironment CHEMOTHERAPY Multi-omics Intestinal microecology 

分 类 号：R735[医药卫生—肿瘤]