多基因检测在早期乳腺癌辅助治疗中的应用价值  

Application of multi-gene panel testing in adjuvant therapy for early breast cancer

作　　者：葛睿 陈飞[2] 李杰 李娟娟[4] 陈涵 Ge Rui;Chen Fei;Li Jie;Li Juanjuan;Chen Han(Department of General Surgery,Huadong Hospital Affiliated to Fudan University,Shanghai 200040,China;Department of General Surgery,Putuo People’s Hospital Affiliated to Tongji University,Shanghai 200060,China;Department of Breast and Thyroid Surgery,Guangzhou Women and Children’s Medical Center,Guangzhou 510623,China;Breast and Thyroid Center,People’s Hospital of Wuhan University,Wuhan 430060,China;Department of General Surgery,PLA Navy 905 Hospital,Shanghai 200052,China)

机构地区：[1]复旦大学附属华东医院普外科,上海200040 [2]同济大学附属普陀人民医院普外科,上海200060 [3]广州医科大学附属妇女儿童医疗中心甲状腺乳腺疾病诊疗中心,广州510623 [4]武汉大学人民医院乳腺甲状腺外科,武汉430060 [5]解放军海军第905医院普外科,上海200052

出　　处：《中华乳腺病杂志(电子版)》2024年第5期257-263,共7页Chinese Journal of Breast Disease(Electronic Edition)

基　　金：北京科创医学发展基金(KC2023-JX-0082-09);同济大学附属普陀区人民医院课题(2023rmky06)。

摘　　要：多基因检测为早期乳腺癌辅助治疗提供了新的策略和方法。随着基因组学技术的不断发展和应用,多基因检测在早期乳腺癌的预后评估、疗效预测和治疗决策中发挥着越来越重要的作用。目前,多基因检测已在激素受体阳性、HER-2阴性乳腺癌的化疗决策、内分泌延长治疗和辅助放射治疗决策中显示出显著价值,同时在三阴性乳腺癌的新辅助治疗中也展现出应用潜力。在HER-2阳性乳腺癌中的应用也有一些探索,但仍需进一步确认其临床价值。本文就目前临床应用的多基因检测工具在早期乳腺癌个体化辅助治疗中的价值进行综述,为临床实践提供参考。Multi-gene panel testing has provided new strategies and approaches for adjuvant therapy in early breast cancer.With continuous development and application of genomic technologies,multi-gene panel testing plays an increasingly important role in prognosis evaluation,efficacy prediction,and treatment decisionmaking in early breast cancer.Currently,multi-gene panel testing has shown a significant value in chemotherapy decision-making,extended endocrine therapy,and adjuvant radiotherapy decision-making for hormonal receptor positive and HER-2 negative(HR+/HER-2-)breast cancer,and potentials in neoadjuvant therapy for triple negative breast cancer.Some explorative studies are conducted in HER-2-positive breast cancer,but its value still needs further confirmation.This article reviewed the application of multi-gene panel testing tools clinically used in individualized adjuvant therapy for early breast cancer,providing a reference for clinical practice.

关 键 词：多基因检测 乳腺肿瘤 辅助治疗 预后 

分 类 号：R737.9[医药卫生—肿瘤]