类似惊恐发作症状的僵人综合征1例  

A case of stiff person syndrome with symptoms similar to panic attack

作　　者：周琬琰 刘彩萍 陈海莹 刘婉莹 项思莹 钱欣怡 李鑫 刘晓华 李冠军[1,2] Zhou Wanyan;Liu Caiping;Chen Haiying;Liu Wanying;Xiang Siying;Qian Xinyi;Li Xin;Liu Xiaohua;Li Guanjun(Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai200030,China;Psychiatric Emergency and Critical Care Diagnosis and Treatment Center,National Center for Mental Disorders,Shanghai200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海200030 [2]国家精神疾病医学中心精神科疑难重症重点专科,上海200030

出　　处：《中华精神科杂志》2025年第1期51-54,共4页Chinese Journal of Psychiatry

基　　金：上海市精神心理疾病临床医学研究中心(19MC1911100)。

摘　　要：僵人综合征是一种罕见的神经系统自身免疫性疾病,其早期症状表现为对轻微刺激产生夸张的惊吓反应和肌肉痉挛症状,常被误诊为惊恐障碍、场所恐惧症等精神障碍。本文报道1例类似惊恐发作的僵人综合征患者,多次就诊分别诊断为肌张力障碍、焦虑障碍以及惊恐障碍等,患者本次住院经过多学科协作诊疗讨论得以确诊。本文中将结合文献探讨如何通过对躯体症状和患者内心体验的准确把握,根据有针对性的神经系统检查和辅助检查作出精准诊断,并进一步凝练临床诊断思路,以提高精神科医生对表现为精神症状的其他学科疾病的识别能力和诊治水平。Stiff person syndrome(SPS)is a rare neuro-immune disorder characterized by exaggerated startle responses and muscle spasms in response to minor stimuli.SPS is often misdiagnosed as panic disorder or agoraphobia.This paper reported a case of a patient with SPS presenting symptoms similar to panic attack.The patient had been misdiagnosed as dystonia,anxiety disorder and panic attack.The patient was finally correctly diagnosed through multiple disciplinary team discussions.This study integrates a comprehensive understanding of symptomatology and patient-reported experiences with targeted neurological evaluations and supplementary diagnostic tools to improve the accuracy of etiological diagnoses.This study aims to enhance the ability of psychiatrists to recognize somatic diseases presenting with psychiatric symptoms and to improve clinical diagnostic and treatment levels.

关 键 词：僵人综合征 惊恐病 多学科协作诊疗 精准诊断 

分 类 号：R741[医药卫生—神经病学与精神病学]