基于纳米技术的热效应在恶性肿瘤放射治疗中的研究进展  

Advances in nanotechnology-based thermal effects in radiotherapy of malignant tumors

作　　者：雷兰 吴竞[1] 劳征虹 吴稚冰 Lei Lan;Wu Jing;Lao Zhenghong;Wu Zhibing(Department of Oncology,Zhejiang Hospital,Hangzhou310000,China;Department of Medical Oncology,Deqing County People's Hospital,Huzhou313000,China)

机构地区：[1]浙江医院肿瘤科,杭州310000 [2]德清县人民医院肿瘤内科,湖州313000

出　　处：《中华放射肿瘤学杂志》2025年第1期88-91,共4页Chinese Journal of Radiation Oncology

摘　　要：放射治疗是当前恶性肿瘤的主要治疗手段之一。如何在提高放射治疗疗效的同时减少其不良反应仍然面临着巨大的挑战。纳米医学的进步为提高肿瘤放射治疗的疗效提供了可能。纳米材料不仅可作为放射增敏剂增强辐射能量,而且可作为纳米载体辅助治疗以对抗肿瘤的抗辐射性。这可能成为探索纳米颗粒放射增敏剂临床转化的新方向。本文综述了基于纳米材料的放射治疗结合光热治疗肿瘤的方法,尤其是如何利用纳米材料来对抗肿瘤抗辐射反应,描述了这些协同疗法相互的增强作用,探讨了放射性纳米医学的潜在挑战和未来前景。Radiotherapy(RT)is one of the main treatment methods for malignant tumors.However,how to improve the efficacy of RT while reducing its side effects is still facing great challenges.The progress of nanomedicine has provided the possibility of improving the curative effect of RT for tumors.Nanomaterials not only act as radiosensitizers to enhance radiation energy,but also act as nanomaterials to provide therapeutic methods against tumor radiation.This may help to explore the new direction of clinical translation of nanoparticle radiosensitizers.In this article,the combination of nanomaterials-based radiotherapy and photothermal therapy for cancer was reviewed.The use of nanomaterials to counter anti-tumor radiation responses was highlighted,and the mutual enhancement of these synergistic therapies was described.In addition,the potential challenges and future prospects of radiation nanomedicine were explored.

关 键 词：放射疗法 纳米材料 光热疗法 磁热疗法 

分 类 号：R730.55[医药卫生—肿瘤]