Long-term survival outcomes of duodenal adenocarcinoma:A cohort study with 15-year single-center experience  

作　　者：Qing-Feng Xie Lian-Sheng Long Yang-Yang Luo Meng-Ting Lu Wai-Kit Ming Li-Ying Zhao Hao Liu 

机构地区：[1]Department of General Surgery,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong Province,China [2]Department of General Surgery,General Hospital of Southern Theater Command,Guangzhou 510515,Guangdong Province,China [3]Department of Infectious Diseases and Public Health,Jockey Club College of Veterinary Medicine and Life Sciences,City University of Hong Kong,Hong Kong 999077,China

出　　处：《World Journal of Gastrointestinal Surgery》2025年第2期45-54,共10页世界胃肠外科杂志(英文)

基　　金：Supported by Natural Science Foundation of Guangdong Province of China,No.2023A1515010785;Key Clinical Technique of Guangzhou,No.2023P-ZD01;Clinical Research Program of Nanfang Hospital,Southern Medical University,No.2021CR003.

摘　　要：BACKGROUND Duodenal adenocarcinoma(DA),a rare gastrointestinal malignancy,lacks clear natural history and management strategies.This study aimed to investigate the long-term outcomes of patients with DA,focusing on long-term survival and the impact of tumor characteristics,surgery,and adjuvant therapy.AIM To bridge this knowledge gap,we conducted a hospital-based cohort study in our 15-year experience with DA aimed at investigating the long-term outcomes of the patients with DA,along with analyzing the impact of the tumor characteristics,operations and adjuvant therapy on survival outcomes.METHODS A retrospective analysis of 208 patients diagnosed with non-ampullary DA at a single institution between 2009 and 2023 was performed.This study used SPSS 26.0 software to make a comprehensive statistical analysis of demographic characteristics,clinical presentation,treatment modalities,and survival outcomes.The effectiveness of surgical resection and adjuvant therapy in 5-year oval survival(OS)and disease-free survival was evaluated using Kaplan-Meier survival curves,the Cox proportional hazards model,and statistical comparisons of survival distributions.RESULTS The median OS time for the cohort was 39 months,with 3-and 5-year OS rates of 51.2%and 43.6%,respectively.Radical resection was performed in 82.6%of cases,and was significantly associated with an improved 5-year OS,with a rate of 57.8%.Adjuvant therapy showed a survival benefit in the specific patient subsets,particularly in tumor stage Ⅱ or Ⅲ tumors,with an improved OS.Adjuvant therapy(hazard ratio=2.71,95%confidence interval:1.30-5.62,P=0.008),pancreatic invasion and advanced tumor stage were identified as significant predictors of OS in multivariate analyses.CONCLUSION Radical operation for DA is associated with a remarkable improvement in the 5-year OS.Importantly,postoperative adjuvant therapy can significantly prolong the OS time in patients with radical operation,especially in patients with stage III.It highlights the necessity for early diagnosis,tai

关 键 词：Duodenal adenocarcinoma Overall survival time Disease-free survival time PANCREATICODUODENECTOMY Adjuvant therapy 

分 类 号：R73[医药卫生—肿瘤]