Genetic factors that predict response and failure of biologic therapy in inflammatory bowel disease  

作　　者：Milena Peruhova Daniela Stoyanova Dimitrina Georgieva Miteva Meglena Kitanova Milko Bozhidarov Mirchev Tsvetelina Velikova 

机构地区：[1]Department of Gastroenterology,University Hospital Heart and Brain,Burgas 1000,Bulgaria [2]Department of Gastroenterology,Military Medical Academy,Sofia 1606,Bulgaria [3]Department of Genetics,Faculty of Biology,Sofia University St.Kliment Ohridski,Sofia 1164,Bulgaria [4]Department of Medical Faculty,Sofia University St.Kliment Ohridski,Sofia 1407,Bulgaria

出　　处：《World Journal of Experimental Medicine》2025年第1期11-23,共13页世界实验医学杂志(英文)

基　　金：Supported by The European Union-Next Generation EU,through the National Recovery and Resilience Plan of the Republic of Bulgaria,No.BG-RRP-2.004-0008。

摘　　要：Inflammatory bowel disease(IBD)represents a significant disease burden marked by chronic inflammation and complications that adversely affect patients’quality of life.Effective diagnostic strategies involve clinical assessments,endoscopic evaluations,imaging studies,and biomarker testing,where early diagnosis is essential for effective management and prevention of long-term complications,highlighting the need for continual advancements in diagnostic methods.The intricate interplay between genetic factors and the outcomes of biological therapy is of critical importance.Unraveling the genetic determinants that influence responses and failures to biological therapy holds significant promise for optimizing treatment strategies for patients with IBD on biologics.Through an indepth examination of current literature,this review article synthesizes critical genetic markers associated with therapeutic efficacy and resistance in IBD.Understanding these genetic actors paves the way for personalized approaches,informing clinicians on predicting,tailoring,and enhancing the effectiveness of biological therapies for improved outcomes in patients with IBD.

关 键 词：Inflammatory bowel disease Genetic predictors Inflammatory bowel disease treatment Biologic therapy Biologic therapy response Genetic markers in inflammatory bowel disease Inflammatory bowel disease treatment failure PHARMACOGENOMICS Biologic therapy efficacy Genetic variability 

分 类 号：R574[医药卫生—消化系统]