Impact of curcumin on gut microbiome  

作　　者：Sangeetha Balaji Naveen Jeyaraman Madhan Jeyaraman Swaminathan Ramasubramanian Sathish Muthu Gabriel Silva Santos Lucas Furtado da Fonseca José Fábio Lana 

机构地区：[1]Department of General Medicine,Government Medical College,Omandurar Government Estate,Chennai 600002,Tamil Nadu,India [2]Department of Orthopaedics,ACS Medical College and Hospital,Dr MGR Educational and Research Institute,Chennai 600077,Tamil Nadu,India [3]Department of Orthopaedics,Orthopaedic Research Group,Coimbatore 641045,Tamil Nadu,India [4]Department of Orthopaedics,Brazilian Institute of Regenerative Medicine,Indaiatuba 13334-170,São Paulo,Brazil [5]Department of Orthopaedics,Government Medical College and Hospital,Karur 639004,Tamil Nadu,India [6]Department of Biotechnology,Karpagam Academy of Higher Education,Coimbatore 641021,Tamil Nadu,India

出　　处：《World Journal of Experimental Medicine》2025年第1期41-52,共12页世界实验医学杂志(英文)

摘　　要：The intricate interplay between natural compounds like curcumin and the gut microbiome has gained significant attention in recent years due to their potential therapeutic implications in various health conditions.Curcumin,a polyphenolic compound derived from turmeric,exhibits diverse pharmacological properties,including anti-inflammatory,antioxidant,and anticancer effects.Understanding how curcumin modulates gut microbiota composition and function is crucial for elucidating its therapeutic mechanisms.This review examines the current literature on the interactions between curcumin and the gut microbiome.A systematic search of relevant databases was conducted to identify studies investigating the effects of curcumin on gut microbial diversity and abundance.Key findings from studies exploring curcumin's efficacy in neurological disorders,gastrointestinal diseases,and metabolic dysfunction are synthesized and discussed.Studies have demonstrated that curcumin supplementation can modulate gut microbiota composition and function,leading to beneficial effects on gut health and homeostasis.Mechanisms underlying curcumin's therapeutic effects include immune modulation,neuroprotection,and inflammation regulation.However,challenges such as poor bioavailability and safety concerns remain significant hurdles to overcome.The interactions between curcumin and the gut microbiome hold promise for therapeutic interventions in a diverse range of health conditions.Further research is needed to optimize curcumin formulations,improve bioavailability,and address safety concerns.

关 键 词：Gut microbiome CURCUMIN NEUROPROTECTION BIOAVAILABILITY 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学] R151.3[医药卫生—基础医学]