散偏汤联合氟桂利嗪治疗偏头痛的疗效观察  

Observation on Curative Effect of Sanbian Decoction Combined with Flunarizine in Treating Migraine

作　　者：成亮 刘彦廷 Liang Cheng;Yanting Liu(Yangzhou University School of Medicine,Yangzhou,Jiangsu 225009)

机构地区：[1]扬州大学医学院,江苏扬州225009

出　　处：《医学研究前沿》2024年第10期26-28,共3页Frontiers of Medical Research

摘　　要：目的本研究旨在探讨散偏汤联合氟桂利嗪与单用氟桂利嗪在治疗偏头痛患者中的临床疗效差异,以评估联合用药的潜在优势。方法采用随机对照试验设计,将符合偏头痛诊断标准的80例患者随机分为治疗组(散偏汤+氟桂利嗪)和对照组(单用氟桂利嗪),每组各40例。治疗组给予散偏汤联合氟桂利嗪治疗,对照组仅给予氟桂利嗪治疗。治疗周期为28天,记录并比较两组患者在治疗前后偏头痛的发作频率、疼痛程度及不良反应发生率。结果治疗结束后,治疗组患者的偏头痛发作频率显著降低至2.1次/月,低于对照组的4.3次/月(P<0.05),治疗后,治疗组的每次偏头痛发作持续时间显著缩短。同时,治疗组的疼痛程度改善率为78.6%,明显高于对照组的54.3%(P<0.05)。在不良反应方面,治疗组的不良反应发生率为12.5%,低于对照组的20.0%,虽然差异未达统计学显著性,但提示联合用药可能有助于降低不良反应。结论散偏汤联合氟桂利嗪在治疗偏头痛中较单用氟桂利嗪具有更显著的疗效,能够更有效地减少偏头痛发作频率和缓解疼痛程度,且可能在一定程度上降低不良反应的发生。这一发现为中西医结合治疗偏头痛提供了新的依据,值得在临床实践中进一步推广和应用。Objective This study was conducted to investigate the difference in clinical efficacy between Sanbias Decoction combined with flunarizine and flunarizine alone in the treatment of migraine patients,in order to evaluate the potential advantages of the combination.Method A randomized controlled trial design was used to randomly divide 80 patients who met the diagnostic criteria of migraine into treatment group(Sandian Decoction+flunarizine)and control group(flunarizine alone),with 40 cases in each group.The treatment group was given Sanbias decoction combined with flunarizine,and the control group was given only flunarizine.The treatment period was 28 days.The frequency of migraine,pain degree and incidence of adverse reactions were recorded and compared between the two groups before and after treatment.Result After treatment,the frequency of migraine attacks in the treatment group was significantly reduced to 2.1 times/month,compared with 4.3 times/month in the control group(P<0.05).After treatment,the duration of each migraine attack in the treatment group was significantly shortened.Meanwhile,the improvement rate of pain degree in the treatment group was 78.6%,which was significantly higher than 54.3%in the control group(P<0.05).In terms of adverse reactions,the incidence of adverse reactions in the treatment group was 12.5%,which was lower than that in the control group(20.0%),although the difference was not statistically significant,it suggested that the combination of drugs may help reduce adverse reactions.Conclusion Sanbias Decoction combined with flunarizine has a more significant effect than flunarizine alone in the treatment of migraine,can more effectively reduce the frequency of migraine attacks and relieve pain,and may reduce the occurrence of adverse reactions to a certain extent.This finding provides a new basis for the treatment of migraine by the combination of traditional Chinese and western medicine,and is worthy of further promotion and application in clinical practice.

关 键 词：散偏汤 氟桂利嗪 偏头痛 

分 类 号：R747.2[医药卫生—神经病学与精神病学]