Potential of ultrasound stimulation and sonogenetics in vision restoration:a narrative review  

作　　者：Jie Ji Chen Gong Gengxi Lu Junhang Zhang Baoqiang Liu Xunan Liu Junhao Lin Patrick Wang Biju B.Thomas Mark S.Humayun Qifa Zhou 

机构地区：[1]Department of Biomedical Engineering,University of Southern California,Los Angeles,CA,USA [2]USC Roski Eye Institute,Keck School of Medicine of University of Southern California,Los Angeles,CA,USA [3]Thomas Lord Department of Computer Science,University of Southern California,Los Angeles,CA,USA [4]Harvard Westlake School,Studio City,CA,USA

出　　处：《Neural Regeneration Research》2025年第12期3501-3516,共16页中国神经再生研究(英文版)

基　　金：supported by R01EY032229(Biomechanical Mapping of the Optic Nerve Head and Peripapillary Sclera Using High Frequency Ultrasonic Elastography);R01EY028662(High-resolution Elastographic Assessment of the Optic Nerve Head);R01EY030126(Non-invasive Ultrasound Stimulated Retinal Prosthesis)(to QZ);Unrestricted Grant to the Department of Ophthalmology from Research to Prevent Blindness,New York,NY(to MSH);the National Eye Institute of the National Institutes of Health under Award Number P30EY029220(to MSH)。

摘　　要：Vision restoration presents a considerable challenge in the realm of regenerative medicine,while recent progress in ultrasound stimulation has displayed potential as a non-invasive therapeutic approach.This narrative review offers a comprehensive overview of current research on ultrasound-stimulated neuromodulation,emphasizing its potential as a treatment modality for various nerve injuries.By examining of the efficacy of different types of ultrasound stimulation in modulating peripheral and optic nerves,we can delve into their underlying molecular mechanisms.Furthermore,the review underscores the potential of sonogenetics in vision restoration,which involves leveraging pharmacological and genetic manipulations to inhibit or enhance the expression of related mechanosensitive channels,thereby modulating the strength of the ultrasound response.We also address how methods such as viral transcription can be utilized to render specific neurons or organs highly responsive to ultrasound,leading to significantly improved therapeutic outcomes.

关 键 词：NEUROMODULATION NON-INVASIVE optic nerve injury retinal degeneration sonogenetics ultrasound stimulation visual restoration 

分 类 号：R77[医药卫生—眼科]