八面体金属中心手性络合物的合成研究进展  

Asymmetric Synthesis of Octahedral Chiral-at-Metal Complexes

作　　者：楚云鹏 马佳佳[1] CHU Yunpeng;MA Jiajia(Frontier Science Center for Transformative Molecules,Shanghai Jiao Tong University,Shanghai 200240)

机构地区：[1]上海交通大学变革性分子前沿科学中心,上海200240

出　　处：《中国基础科学》2024年第5期39-46,52,共9页China Basic Science

基　　金：国家重点研发计划青年科学家项目(2023YFA1508900)。

摘　　要：与四取代碳原子显示出正四面体的几何构象相比,配位饱和的后过渡金属离子通常为六配位形式,其展示出正八面体几何构象且拥有手性特征,被称为八面体金属中心手性络合物。近年来,这类八面体金属中心手性络合物在药物化学、材料科学和均相催化等多个领域均展现出重要的应用价值。归纳和总结此类手性分子的合成策略,主要包括手性色谱分离技术、手性配体诱导的不对称合成、手性助剂介导的不对称合成和不对称催化合成等。通过对上述合成策略进行分析,进一步探讨该领域存在的难点,为相关合成方法以及理论的革新提供参考。In contrast to tetra-substituted carbon atoms which display a regular tetrahedral geometry,saturated coordination late transition metal ions which are called octahedral chiral-at-metal complexes are typically sixcoordinated,exhibiting an octahedral geometry with chiral properties.Over the past decades,octahedral chiral-at-metal complexes have found significant applications in various fields,including medicinal chemistry,materials science,and homogeneous catalysis.This paper summarizes the preparation strategies for such chiral molecules,including chiral chromatography separation techniques,chiral ligand-induced asymmetric synthesis,chiral auxiliary-assisted asymmetric synthesis,and asymmetric catalytic synthesis.By analyzing these synthetic strategies,this paper further discusses the challenges in this field,providing perspective for transformative research in related synthesis methods.

关 键 词：金属中心手性 手性色谱 手性配体 手性助剂 不对称催化 

分 类 号：O641[理学—物理化学]