容积旋转调强放疗与三维适形放疗在食管癌患者中的应用效果比较  

Comparison of application effects of volume rotation intensity-modulated radiotherapy and three-dimensional conformal radiotherapy in patients with esophageal cancer

作　　者：王小翠 奚和明 赵雪松 杨振宇 赵小静[1] 何佳欣 金秀 WANG Xiaocui;XI Heming;ZHAO Xuesong;YANG Zhenyu;ZHAO Xiaojing;HE Jiaxin;JIN Xiu(Department of Radiotherapy of Anyang People’s Hospital,Anyang 455000 Henan,China)

机构地区：[1]安阳市人民医院放疗科,河南安阳455000

出　　处：《中国民康医学》2025年第2期122-124,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:比较容积旋转调强放疗与三维适形放疗在食管癌患者中的应用效果。方法:回顾性分析2017—2022年该院收治的80例食管癌患者的临床资料,按照放疗方法不同将其分为观察组和对照组各40例。两组均予以卡培他滨片同步化疗,在此基础上,对照组采用三维适形放疗,观察组采用容积旋转调强放疗。比较两组临床疗效、靶区剂量学参数[计划靶区(PTV)总剂量、适形度指数(CI)、均匀度指数(HI)]、危及器官剂量和不良反应发生率。结果:观察组客观缓解率(ORR)为65.00%(26/40),高于对照组的42.50%(17/40),差异有统计学意义(P<0.05);观察组PTV总剂量、HI低于对照组,CI高于对照组,差异均有统计学意义(P<0.05);观察组双肺平均剂量、心脏平均剂量、脊髓最大剂量均低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为65.00%(26/40),低于对照组的95.00%(38/40),差异有统计学意义(P<0.05)。结论:容积旋转调强放疗应用于食管癌患者可提高ORR,改善靶区剂量学参数,减小危及器官剂量,降低不良反应发生率,效果优于三维适形放疗。Objective:To compare application effects of volume rotation intensity-modulated radiotherapy and three-dimensional conformal radiotherapy in patients with esophageal cancer.Methods:The clinical data of 80 patients with esophageal cancer admitted to the hospital from 2017 to 2022 were retrospectively analyzed.According to different radiotherapy methods,they were divided into observation group and control group,h 40 cases in each group.Both groups were treated with Capecitabine.On this basis,the control group was treated with three-dimensional conformal radiotherapy,while the observation group was treated with volume rotation intensity-modulated radiotherapy.The clinical efficacy,the target dosimetric parameters[total dose of planned target volume(PTV),conformal index(CI),homogeneity index(HI)]levels,the dose of organs at risk,and the incidence of adverse reactions were compared between the two groups.Results:The objective remission rate(ORR)of the observation group was 65.00%(26/40),which was higher than 42.50%(17/40)of the control group,and the difference was statistically significant(P<0.05).The total dose of PTV and HI in the observation group were lower than those in the control group,the CI level was higher than that in the control group,and the differences were statistically significant(P<0.05).The average dose of both lungs,the average dose of heart and the maximum dose of spinal cord in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was 65.00%(26/40),which was lower than 95.00%(38/40)in the control group,and the difference was statistically significant(P<0.05).Conclusions:The volume rotation intensity-modulated radiotherapy in the patients with esophageal cancer can improve the ORR,improve the dosimetric parameter levels of the target area,reduce the dose of the organs at risk,and reduce the incidence of adverse reactions.Moreover,it is superior to three-dimension

关 键 词：容积旋转调强放疗 三维适形放疗 食管癌 靶区 剂量学 客观缓解率 

分 类 号：R735.1[医药卫生—肿瘤]