High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor  

作　　者：Jie Hu Weihao Lin Liyang Shao Chenlong Xue Fang Zhao Dongrui Xiao Yang Ran Yue Meng Panpan He Zhiguang Yu Jinna Chen Perry Ping Shum 

机构地区：[1]Department of Electronic and Electrical Engineering,Southern University of Science and Technology,Shenzhen 518055,China [2]School of Electrical Information Engineering,Hunan Institute of Technology,Hengyang 421002,China [3]Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications,Institute of Photonics Technology,Jinan University,Guangzhou 510632,China [4]Department of Clinical Laboratory,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 511436,China [5]Medcaptain Medical Technology Co.,Ltd.,Shenzhen 518055,China

出　　处：《Opto-Electronic Advances》2024年第12期61-77,共17页光电进展(英文)

基　　金：supported in part by the Science and Technology Department of Guangdong Province(2021A0505080002);Department of Natural Resources of Guangdong Province(GDNRC[2022]No.22);Science,Technology and Innovation Commission of Shenzhen Municipality(20220815121807001);Hunan Provincial Natural Science Foundation of China(under Grant Nos.2023JJ30209);Hunan Provincial Education Department Science Research Fund of China(under Grant Nos.22B0862).

摘　　要：The specific detection of tumor markers is crucial in early tumor screening and subsequent treatment processes.To ac-curately distinguish the signal response caused by trace markers,the high demodulation resolution of the sensor is necessary.In this paper,we propose a dual-wavelength fiber laser sensing system enhanced with microwave photonics de-modulation technology to achieve high-resolution tumor marker detection.This sensing system can simultaneously perform spectral wavelength-domain and frequency-domain analyses.Experimental results demonstrate that this system's refractive index(RI)sensitivity reaches 1083 nm/RIU by wavelength analysis and-1902 GHz/RIU by frequency analysis,with ideal detection resolutions of 1.85×10^(-5)RIU and 5.26×10^(-8)RIU,respectively.Compared with traditional wavelength domain analysis,the demodulation resolution is improved by three orders of magnitude,based on the same sensing structure.To validate its biosensing performance,carcinoembryonic antigen-related cell adhesion molecule 5(CEACAM5)is selected as the detection target.Experimental results show that the improved sensing system has a limit of detection(LOD)of 0.076 ng/mL and a detection resolution of 0.008 ng/mL.Experimental results obtained from human serum samples are consistent with clinical data,highlighting the strong clinical application potential of the proposed sens-ing system and analysis method.

关 键 词：optical fiber sensor optical fiber laser microwave photonics demodulation high-resolution detection tumor marker detection 

分 类 号：R73[医药卫生—肿瘤]