Rh(Ⅲ)-Catalyzed Aminoalkylation of Alkenes with Diazo Compounds toward Functionalized Isoindolinones  

Rh(Ⅲ)催化烯烃与重氮化物氨基烷基化反应构筑异吲哚啉酮

作　　者：Yuying Liu Zhanwei Fu Chao Yang Mupeng Luo Shurong Ban Shouguo Wang 刘玉英;符展维;杨超;罗木鹏;班树荣;王守国(山西医科大学药学院,太原030001;山西医科大学,慢性肾脏病教育部医药基础研究创新中心,太原030001;山西医科大学药物合成与制剂新技术山西省重点实验室,太原030001;中国科学院深圳先进技术研究院,深圳518055)

机构地区：[1]School of Pharmacy,Shanxi Medical University,Taiyuan 030001 [2]Medicinal Basic Research Innovation Center of Chronic Kidney Disease,Ministry of Education,Shanxi Medical University,Taiyuan 030001 [3]Shanxi Provincial Key Laboratory of Drug Synthesis and Novel Pharmaceutical Preparation Technology,Shanxi Medical University,Taiyuan 030001 [4]Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055

出　　处：《有机化学》2024年第11期3505-3517,共13页Chinese Journal of Organic Chemistry

基　　金：山西省自然科学基金(No.202303021221131);山西省特色药物研制工程研究中心和深圳市科技创新委员会(Nos.JCYJ20210324101810028,JCYJ-20220818101601004,JCYJ20220818095801004)资助项目.

摘　　要：A[Cp*RhCl_(2)]_(2)-catalyzed intramolecular annulation reaction via aminoalkylation of alkenes with diazo compounds has been developed to construct highly-functionalized isoindolinones.This approach exhibits step economy,mild reaction conditions,and good functional group tolerance,facilitating access to a wide range of highly-valuable functionalized isoindolinones with high level of yields(up to 99%yield).报道了[Cp*RhCl_(2)]_(2)催化的烯烃与重氮化合物的氨基烷基化串联环化反应,实现了一系列3,3-双取代异吲哚啉酮的高效、快速构建.该反应具有反应条件温和、反应选择性好以及底物适用范围广等优点,为一系列具有应用价值的异吲哚啉酮骨架化合物的合成提供了一种原子经济性方法.

关 键 词：aminoalkylation reaction annulation reaction ISOINDOLINONE Rh(Ⅲ)-catalysis diazo compounds 

分 类 号：O621.251[理学—有机化学] O626[理学—化学]