肿瘤异常蛋白联合CT在肺癌早期筛查中的应用研究  

Application study of tumor abnormal protein combined with CT in early screening of lung cancer

作　　者：钟安桥[1] 范红霞 张海津[1] 杜海莲[1] 王婷 刘菲 ZHONG An-qiao;FAN Hong-xia;ZHANG Hai-jin;DU Hai-lian;WANG Ting;LIU Fei(Department of Respiratory and Critical Care Medicine,Weifang City Yidu Central Hospital,Qingzhou Shandong Province 262500,China;Department of Acupuncture and Moxibustion,Shandong Province Weifang City Qingzhou Hospital of Traditional Chinese Medicine)

机构地区：[1]潍坊市益都中心医院呼吸与危重症医学科,山东青州262500 [2]山东省潍坊市青州市中医院针灸科

出　　处：《中国城乡企业卫生》2024年第12期21-23,共3页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：目的分析肿瘤异常蛋白联合CT在肺癌早期筛查中的应用价值,为提升临床肺癌早期筛查的效果提供参考。方法选取潍坊市益都中心医院2021年1月—2022年12月收治的常规筛查人员300例作为观察对象,均采取肿瘤异常蛋白与CT检查,肿瘤异常蛋白选择测量异常糖链糖蛋白,分析不同筛查方式的疾病诊断结果(灵敏度、特异度、诊断准确率、阳性预测值、阴性预测值)。结果肿瘤异常蛋白与CT对肺癌的筛查灵敏度、特异度、诊断准确率、阳性预测值、阴性预测值均相对较高,但联合检查的灵敏度、特异度、诊断准确率、阳性预测值、阴性预测值高于单独检查,差异均有统计学意义(P<0.05);肿瘤异常蛋白与CT检查间的灵敏度、特异度、诊断准确率、阳性预测值、阴性预测值比较,差异均无统计学意义(P>0.05)。结论在肺癌疾病的早期筛查过程中,采取肿瘤异常蛋白与CT检查均能获得较高的诊断价值,并且肿瘤异常蛋白联合CT能提高疾病诊断灵敏度、特异度、诊断准确率、阳性预测值、阴性预测值,方便在早期检出肺癌疾病,采取进一步诊断与治疗,对提高肺癌生存率有重要作用,值得临床推广应用。Objective To analyze the application value of tumor abnormal protein combined with CT in early screening of lung cancer,in order to provide reference for improving the effectiveness of clinical early screening of lung cancer.Methods A total of 300 routine screening personnel admitted to Weifang City Yidu Central Hospital from January 2021 to December 2022 were selected as the observation objects.Abnormal tumor proteins and CT examination were performed,and abnormal glycan glycoproteins were measured for tumor abnormal proteins.The disease diagnosis results(sensitivity,specificity,diagnostic accuracy,positive predictive value,negative predictive value)of different screening methods were analyzed.Results The sensitivity,specificity,diagnostic accuracy,positive predictive value and negative predictive value of abnormal tumor protein and CT in screening lung cancer were relatively high.However,the sensitivity,specificity,diagnostic accuracy,positive predictive value and negative predictive value of combined examination were higher than those of individual examination,and the differences were statistically significant(P<0.05);there were no statistically significant differences in the sensitivity,specificity,diagnostic accuracy,positive predictive value and negative predictive value between abnormal tumor proteins and CT examination(P>0.05).Conclusion In the early screening process of lung cancer,both tumor abnormal protein and CT examination could obtain high diagnostic value.Moreover,the combination of tumor abnormal protein and CT could improve disease diagnosis sensitivity,specificity,diagnostic accuracy,positive predictive value and negative predictive value.This facilitated the early detection of lung cancer and further diagnosis and treatment,which played an important role in improving lung cancer survival rate and was worthy of clinical promotion and application.

关 键 词：异常糖链糖蛋白 CT 肺癌 早期 筛查 

分 类 号：R734.2[医药卫生—肿瘤]