血清YKL-40、TAP、M-CSF在子宫颈癌患者中的表达及意义  

Expression and significance of serum YKL-40,TAP and M-CSF in patients with cervical cancer

作　　者：石琳 钟政 沈仕莲 陈莉[1] SHI Lin;ZHONG Zheng;SHEN Shilian;CHEN Li(Department of Obstetrics and Gynecology,Qingdao Traditional Chinese Medicine Hospital(Qingdao Hiser Hospital)Qingdao Hiser Hospital Affiliated of Qingdao University,Qingdao Shandong 266033,China;Department of Pediatrics,Qingdao Traditional Chinese Medicine Hospital(Qingdao Hiser Hospital)Qingdao Hiser Hospital Affiliated of Qingdao University,Qingdao Shandong 266033,China)

机构地区：[1]青岛大学附属青岛市海慈医院(青岛市中医医院)妇产科,山东青岛266033 [2]青岛大学附属青岛市海慈医院(青岛市中医医院)儿科,山东青岛266033

出　　处：《中国妇产科临床杂志》2025年第1期15-17,共3页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：山东省中医药科技项目(2019WS0303)。

摘　　要：目的探讨血清人软骨糖蛋白39(YKL-40)、肿瘤异常蛋白(TAP)、巨噬细胞集落刺激因子(M-CSF)在子宫颈癌患者中的表达及意义。方法选择2018年2月至2023年5月在青岛大学附属青岛市海慈医院治疗的102例子宫颈癌患者作为观察组,另取本院同期体检健康的女性90例作为对照组。比较两组的血清YKL-40、TAP、M-CSF水平,并比较不同脉管浸润、TNM分期、组织学分化、淋巴结转移及预后子宫颈癌患者的血清YKL-40、TAP、M-CSF水平。结果观察组血清YKL-40、TAP、M-CSF水平均明显高于对照组(P<0.05);脉管浸润、Ⅲ~Ⅳ期、组织学中低分化、淋巴结转移子宫颈癌患者的血清YKL-40、TAP、M-CSF水平均高于无脉管浸润、Ⅰ~Ⅱ期、组织学中高分化、无淋巴结转移子宫颈癌患者(P<0.05);死亡组子宫颈癌患者的血清YKL-40、TAP、M-CSF水平均明显高于生存组(P<0.05)。结论子宫颈癌患者的血清YKL-40、TAP和M-CSF表达水平升高,与子宫颈癌病理特征、预后密切相关,检测血清YKL-40、TAP、M-CSF水平变化有助于更精准地评估患者的病情进展和预后。Objective To investigate the expression and significance of serum human chondroglycoprotein 39(YKL-40),abnormal tumor protein(TAP)and macrophage colony-stimulating factor(M-CSF)in patients with cervical cancer.Methods A total of 102 patients of cervical cancer in Qingdao Haici Hospital affiliated to Qingdao University from February 2018 to 2023 were selected as the observation group,and another 90 healthy women were selected as the control group.The serum levels of YKL-40,TAP and M-CSF were compared between the two groups,and the serum levels of YKL-40,TAP and M-CSF in patients with different vascular invasion,TNM stage,histological differentiation,lymph node metastasis and prognosis of cervical cancer were compared.Results A total of 102 patients of cervical cancer in Qingdao Haici Hospital affiliated to Qingdao University from February 2018 to 2023 were selected as the observation group,and another 90 healthy women were selected as the control group.The serum levels of YKL-40,TAP and M-CSF were compared between the two groups,and the serum levels of YKL-40,TAP and M-CSF in patients with different vascular invasion,TNM stage,histological differentiation,lymph node metastasis and prognosis of cervical cancer were compared.Conclusions Serum YKL-40,TAP,and M-CSF expression levels are elevated in patients with cervical cancer,and their expression levels are closely related to the pathologic features and prognosis of cervical cancer,and detecting changes in the levels of serum YKL-40,TAP,and M-CSF can help to more accurately assess the progression of the patients'disease and prognosis.

关 键 词：子宫颈癌 人软骨糖蛋白39 肿瘤异常蛋白 巨噬细胞集落刺激因子 

分 类 号：R737.33[医药卫生—肿瘤]