三阴性乳腺癌组织中lncRNA HCG11 mRNA和miR-4465水平表达与临床病理特征及预后的相关性研究  

Correlation between lncRNA HCG11 mRNA and miR-4465 Expression Levels and Clinicopathological Features and Prognosis in Triple-negative Breast Cancer Tissues

作　　者：张玲 徐海燕 王强力 杨懿瑾 陈彬 ZHANG Ling;XU Haiyan;WANG Qiangli;YANG Yijin;CHEN Bin(Department of Oncology,Jiulong Hospital of Suzhou City,Jiangsu Suzhou 215021,China)

机构地区：[1]苏州市九龙医院肿瘤内科,江苏苏州215021

出　　处：《现代检验医学杂志》2025年第1期84-89,共6页Journal of Modern Laboratory Medicine

摘　　要：目的 探讨长链非编码RNA HLA复合体11(lncRNA HCG11)mRNA,miR-4465在三阴性乳腺癌(TNBC)患者中的表达及临床意义。方法 收集2017年6月~2020年6月在苏州市九龙医院住院治疗的110例三阴性乳腺癌患者的临床病理资料,分析lncRNA HCG11 mRNA,miR-4465表达及其临床意义。结果 癌组织lncRNA HCG11 mRNA(1.81±0.53)表达高于癌旁组织(0.87±0.13),miR-4465(0.68±0.14)表达低于癌旁组织(1.09±0.18),差异具有统计学意义(t=18.066,18.857,均P<0.05)。Pearson分析结果显示lncRNA HCG11 mRNA与miR-4465表达呈负相关(r=-0.443,P<0.001);TNM分期Ⅲ+Ⅳ期、淋巴结发生转移的癌组织中lncRNA HCG11mRNA高表达与miR-4465低表达患者比例高于TNM分期Ⅰ+Ⅱ期、无淋巴结发生转移患者比例,差异具有统计学意义(χ^(2)=6.614,18.510;8.093,22.976,均P <0.05)。lncRNA HCG11 mRNA高表达患者三年生存率低于lncRNA HCG11mRNA低表达患者,miR-4465高表达患者三年生存率高于miR-4465低表达患者(Log-rankχ^(2)=14.45,13.39,均P<0.05);死亡组临床分期为Ⅲ+Ⅳ期、发生淋巴结转移的患者比例高于生存组(χ^(2)=12.667,18.026,均P<0.05);lncRNA HCG11mRNA(HR=2.623,95%CI:1.344~5.118)是三阴性乳腺癌患者三年内死亡的危险因素,miR-4465(HR=0.891,95%CI:0.821~0.967)是保护因素(P<0.05)。结论 三阴性乳腺癌中lncRNA HCG11 mRNA高表达、miR-4465低表达与患者临床病理特征及预后有关,有望成为预测三阴性乳腺癌的预后标志物。Objective To investigate the expression and clinical significance of long non-codingRNA HCG11(lncRNA HCG11)mRNA and microRNA(miR)-4465 in patients with triple-negative breast cancer(TNBC).Methods The clinicopathological data of 110 TNBC patients hospitalized in Jiulong Hospital of Suzhou from June 2017 to June 2020 were collected,and the clinical significance of the expression of lncRNA HCG11mRNA and miR-4465 was analyzed.Results The expression of lncRNA HCG11 mRNA(1.81±0.53)in cancer tissues was higher than that in adjacent tissues(0.87±0.13),while the expression of miR-4465(0.68±0.14)was lower than that in adjacent tissues(1.09±0.18),and the differences were statistically significant(t=18.066,18.857,all P<0.05).The results of Pearson analysis showed that lncRNA HCG11mRNA was negatively correlated with the expression of miR-4465(r=-0.443,P<0.001).The proportion of patients with high expression of lncRNA HCG11mRNA and low expression of miR-4465 in cancer tissues with lymph node metastasis in TNM stage Ⅲ+Ⅳ was higher than that in TNM stage Ⅰ+Ⅱ,and the proportion of patients without lymph node metastasis was higher(χ^(2)=6.614,18.510;8.093,22.976,all P<0.05)The 3-year survival rate of lncRNA HCG11mRNA patients with high expression was lower than that of lncRNA HCG11mRNA patients with low expression,and the 3-year survival rate of patients with high expression of miR-4465 was higher than that of patients with low expression of miR-4465(Log-rankχ^(2)=14.45,13.39,all P<0.05).The proportion of patients with clinical stageⅢ+Ⅳin death group was higher than that in survival group(χ^(2)=12.667,18.026,all P<0.05).LncRNA HCG11mRNA(HR=2.623,95%CI:1.344~5.118)was risk factors for 3-year death in TNBC patients,while miR-4465(HR=0.891,95%CI:0.821~0.967)was a protective factor(P<0.05).Conclusion The high expression of lncRNA HCG11 mRNA and the low expression of miR-4465 in triple negatire breast cancer were related to the clinicopathological characteristics and prognosis of patients,and are expected to become p

关 键 词：三阴性乳腺癌 长链非编码RNA HLA复合体11 微小RNA-4465 

分 类 号：R737.9[医药卫生—肿瘤] R730.43[医药卫生—临床医学]