度普利尤单抗治疗苔藓样皮肤淀粉样变一例  

Primary cutaneous amyloidosis successfully treated with dupilumab:a case report

作　　者：赖美妍 龙博泉 叶智铭 龙绮 杨岚 游馥榕 郭红卫 LAI Meiyan;LONG Boquan;YE Zhiming;LONG Qi;YANG Lan;YOU Furong;GUO Hongwei(Department of Dermatology,The Second Affiliated Hospital of Guangdong Medical University,Zhanjiang 524003,China;First School of Clinical Medicine,Guangdong Medical University,Zhanjiang 524003,China)

机构地区：[1]广东医科大学附属第二医院皮肤科,广东湛江524003 [2]广东医科大学第一临床医学院,广东湛江524003

出　　处：《中国麻风皮肤病杂志》2025年第2期120-122,共3页China Journal of Leprosy and Skin Diseases

基　　金：湛江市科技项目(编号:2021A05093)。

摘　　要：原发性苔藓样皮肤淀粉样变治疗难度大且复发率高,尚无标准化治疗方案。本文报道一例度普利尤单抗成功治疗原发性苔藓样皮肤淀粉样变。患者项背部、四肢丘疹伴瘙痒2年,经组织病理学确诊。常规治疗效果不佳,给予度普利尤单抗治疗,治疗当日患者瘙痒即减轻,12周后皮疹消退。停药后2个月,未见新发皮疹及不良反应。Primary cutaneous amyloidosis(PCA)is a refractory disease with high recurrence rate and no standardized treatment.This article reports a case of successful treatment of PCA with dupilumab.The patient presented with papules with itching on the neck and back,and limbs for 2 years,which was confirmed by pathology.Conventional treatments were ineffective,and dupilumab therapy was administered.On the day of treatment,the patient s itching was alleviated,and after 12 weeks,the skin rashes subsided.Two months after drug withdrawal,no new skin rashes or adverse reactions were observed.

关 键 词：度普利尤单抗 原发性皮肤淀粉样变性 苔藓样淀粉样变 

分 类 号：R73[医药卫生—肿瘤]