乌拉地尔联合甘露醇治疗高血压性脑出血的临床疗效及对患者神经功能的影响分析  

Analysis of the Clinical Efficacy of Urapidil Combined with Mannitol in the Treatment of Hypertensive Intracerebral Hemorrhage and Its Impact on the Neurological Function of Patients

作　　者：方仲宁 戴伟川[1] 蔡文华[1] 蔡沉逐 齐震 FANG Zhongning;DAI Weichuan;CAI Wenhua;CAI Chenzhu;QI Zhen(Department of Neurosurgery,Jinjiang City Hospital(Shanghai Sixth People's Hospital Fujian Hospital),Jinjiang,Fujian,362200,China)

机构地区：[1]晋江市医院(上海市第六人民医院福建医院)神经外科,福建晋江362200

出　　处：《中外医疗》2024年第35期119-123,共5页China & Foreign Medical Treatment

摘　　要：目的探究乌拉地尔联合甘露醇治疗高血压性脑出血的临床疗效及对患者神经功能的影响。方法回顾性分析2022年1月-2023年12月晋江市医院神经外科98例高血压性脑出血患者的临床资料,根据治疗方式不同分两组,各49例。两组均给予常规治疗,包括吸氧、纠正水电解质紊乱、营养神经、脑保护,对照组静脉滴注甘露醇,研究组在对照组治疗基础上使用乌拉地尔。对比两组临床疗效,入院当天及治疗3周后,比较两组血压水平(收缩压、舒张压、平均动脉压)、神经功能(神经肽Y、同型半胱氨酸、神经元特异性烯醇化酶、中枢神经特异性蛋白100β)、炎症因子(肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-2、白细胞介素-6)。结果研究组治疗有效率为97.96%(48/49),高于对照组的83.67%(41/49),差异有统计学意义(χ^(2)=4.405;P<0.05)。治疗前,两组患者血压水平、神经功能指标、炎症因子指标比较,差异均无统计学意义(P均>0.05)。治疗后,两组患者血压水平低于治疗前,且研究组收缩压水平为(145.37±8.19)mmHg,舒张压水平为(91.05±6.78)mmHg,平均动脉压水平(103.15±6.25)mmHg,均低于对照组的(176.79±9.26)mmHg、(101.73±7.31)mmHg与(119.73±7.36)mmHg,差异均有统计学意义(t=17.791,7.498,12.020;P均<0.05)。两组患者神经功能指标低于治疗前,且研究组指标水平低于对照组,差异均有统计学意义(P均<0.05)。治疗后,两组患者炎症因子水平低于治疗前,且研究组炎症因子水平低于对照组,差异均有统计学意义(P均<0.05)。结论高血压性脑出血患者应用乌拉地尔联合甘露醇治疗临床疗效较好,能够促进患者神经功能恢复,降低血压水平,改善炎症因子水平。Objective To explore the clinical efficacy of urapidil combined with mannitol in the treatment of hypertensive intracerebral hemorrhage and its impact on the neurological function of patients.Methods The clinical data of 98 patients with hypertensive intracerebral hemorrhage in the Department of Neurosurgery of Jinjiang City Hospital from January 2022 to December 2023 were retrospectively analyzed.According to different treatment methods,the patients were divided into two groups,with 49 cases in each group.Both groups were given routine treatments,including oxygen inhalation,correction of water and electrolyte disorders,nerve nutrition,brain protection.The control group was given intravenous infusion of mannitol,and the study group was given urapidil on the basis of the treatment of the control group.The clinical efficacies of the two groups were compared.On the day of admission and three weeks after treatment,the blood pressure levels(systolic blood pressure,diastolic blood pressure,mean arterial pressure),neurological functions(neuropeptide Y,homocysteine,neuron-specific enolase,central nervous system-specific protein 100β),and inflammatory factors(tumor necrosis factor-α,interleukin-1β,interleukin-2,interleukin-6)of the two groups were compared.Results The effective rate of treatment in the study group was 97.96%(48/49),which was higher than that of the control group 83.67%(41/49),and the difference was statistically significant(χ^(2)=4.405;P<0.05).Before treatment,there were no statistically significant differences in the blood pressure levels,neurological function indicators,and inflammatory factor indicators between the two groups(all P>0.05).After treatment,the blood pressure levels of both groups were lower than those before treatment,the systolic blood pressure level of the study group was(145.37±8.19)mmHg,the diastolic blood pressure level was(91.05±6.78)mmHg,and the mean arterial pressure level was(103.15±6.25)mmHg,which were all lower than those of the control group(176.79±9.26)mmHg,(101.73±7

关 键 词：乌拉地尔 甘露醇 高血压性脑出血 临床疗效 神经功能 血压水平 

分 类 号：R743[医药卫生—神经病学与精神病学]