肝细胞核因子4α在胃癌及癌前病变中的研究进展  

Research progress of hepatocyte nuclear factor 4αin gastric cancer and precancerous lesions

作　　者：杨宇燕 赵唯含 王思宇 董思琪 YANG Yuyan;ZHAO Weihan;WANG Siyu;DONG Siqi(First Clinical Medical College,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712000,China;不详)

机构地区：[1]陕西中医药大学第一临床医学院,陕西咸阳712000 [2]陕西中医药大学附属医院消化二科,陕西咸阳712000

出　　处：《中国临床研究》2025年第1期6-10,共5页Chinese Journal of Clinical Research

基　　金：国家自然科学基金项目(81804082);陕西省自然科学基金(2023-JC-YB-667);陕西省中医药管理局科研项目(SZY-KJCYC-2023-019)。

摘　　要：肝细胞核因子4α(HNF4α)是核受体超家族的成员,一种与特定基因启动子结合的蛋白质。它控制功能基因的表达,还参与许多细胞过程的调节,是人类组织和器官发育的关键调节因子之一。大量证据表明HNF4α的异常表达与癌细胞的增殖、分化、进展和转移有关。近年来,越来越多的研究证实HNF4α可通过多种通路参与胃癌及癌前病变的进程,已被证明是胃癌中的致癌基因。本文就HNF4α在胃癌及癌前病变发生发展中的作用进行总结,对HNF4α作为胃癌生物标志物和治疗靶点的潜在临床用途进行综述,以期为胃癌及癌前病变的新药研发提供新思路。Hepatocyte nuclear factor 4α(HNF4α)is a member of the nuclear receptor superfamily,a kind of protein that binds to a specific gene promoter.It controls the expression of functional genes and is also involved in the regulation of many cellular processes,and is one of the key factors for the development of human tissues and organs.A large amount of evidences have shown that abnormal expression of HNF4αis related to the proliferation,differentiation,progression and metastasis of cancer cells.In recent years,more and more studies have confirmed that HNF4αcan participate in the process of gastric cancer and precancerous lesions through multiple pathways,and has been proved to be an oncogene in gastric cancer.This article summarizes the role of HNF4αin the development and progression of gastric cancer and precancerous lesion,and reviews the potential clinical applications of HNF4αas a biomarker and therapeutic target for gastric cancer,in order to provide new ideas for the development of novel drugs for gastric cancer and precancerous lesions.

关 键 词：肝细胞核因子4Α 胃癌 癌前病变 致癌基因 生物标志物 治疗靶点 

分 类 号：R735.2[医药卫生—肿瘤]