甲状腺结节患者血浆galectin-3及ck-19水平分析  

Plasma Galectin-3 and CK-19 Levels in Patients with Thyroid Nodules

作　　者：司玲敏 SI Ling-min(Clinical Laboratory Department,Shan Xian Dongda Hospital,Shandong Heze 274300)

机构地区：[1]单县东大医院检验科,山东菏泽274300

出　　处：《医学检验与临床》2024年第12期22-25,60,共5页Medical Laboratory Science and Clinics

摘　　要：目的:分析甲状腺结节(TN)患者血浆半乳糖凝集素-3(Gal-3)及细胞角蛋白19(CK-19)水平变化及其临床意义。方法:将2022年1月-2023年1月在本院内分泌科收治的疑似甲状腺恶性结节的124例TN患者纳入研究范围,组织病理确诊恶性结节39例,良性结节85例,比较不同结节性质的TN患者血浆Galectin-3、CK-19水平,分析血浆Galectin-3、CK-19水平及其联合对TN性质的诊断价值;并比较不同临床病理特征的甲状腺恶性结节患者血浆Galectin-3、CK-19水平。结果:恶性TN患者血浆Galectin-3及CK-19高于良性TN患者(P<0.05),恶性TN患者血浆Galectin-3≥0.75ng/mL、CK-19≥2.70ng/mL比例显著高于良性TN患者;以病理结果为金标准,单一Galectin-3、CK-19、并联实验、串联试验诊断甲状腺恶性结节的敏感性、准确性、阳性预测值、阴性预测值差异均无统计学意义(P>0.05),串联试验的特异性显著高于CK-19、并联试验(P<0.05),串联实验的Kappa值最高;不同性别、年龄、病理类型及淋巴结转移情况的甲状腺恶性结节患者中,Galectin-3≥0.97 ng/mL、CK-19≥3.58ng/mL比例差异无统计学意义(P>0.05)。结论:恶性TN患者血浆Galectin-3及CK-19呈较高水平,血浆Galectin-3及CK-19串联实验对TN性质有较高的鉴别诊断效能,但血浆Galectin-3及CK-19与恶性TN患者临床病理的关系仍有待探究。Objective:To analyze the changes and clinical significance of plasma galectin-3(Gal-3)and cytokeratin 19(CK-19)levels in patients with thyroid nodules(TN).Methods:A total of 124 patients with suspected malignant TN who were admitted to the hospital from January 2022 to January 2023 were included in the study.39 cases of malignant nodules and 85 cases of benign nodules were confirmed by histopathology.Plasma Gal-3 and CK-19 levels in patients with different nature of TN were compared.The value of plasma Galectin-3 level,CK-19 level,and their combination for diagnosing the nature of TN was analyzed.Plasma Gal-3 and CK-19 levels in patients with malignant thyroid nodules and different clinicopathological features were compared.Results:Plasma Gal-3 and CK-19 levels were higher in patients with malignant TN than in patients with benign TN(P<0.05),The proportions of plasma Gal-3≥0.75 ng/mL and CK-19≥2.70 ng/mL were significantly higher in patients with malignant TN than in patients with benign TN.With pathological results as the golden standard,no significant diferences were found in the sensitivity,accuracy,positive predictive value and negative predictive value of Galectin-3 or CK-19 alone,parallel test and serial test in the diagnosis of malignant TN(P≥0.05).The specificity of serial test was significantly higher than that of CK-19 alone and parallel test(P<0.05),and the Kappa value of serial test was the highest.There were no statistically significant differences in the proportions of plasma Gal-3≥0.97ng/mL and CK-19≥3.58ng/mL between malignant TN patients of different gender,age,pathological types,patients with and without lymph node metastasis(P>0.05).Conclusion:Patients with malignant TN have higher plasma Gal-3 and CK-19 levels.Plasma Gal-3 and CK-19 serial test has a high eficiency in diagnosing the nature of TN.However,the relationship between plasma Gal-3 and CK-19 and clinical pathology in patients with malignant TN needs further study.

关 键 词：甲状腺结节 半乳糖凝集素-3 细胞角蛋白19 

分 类 号：R73[医药卫生—肿瘤]