DSCC1在癌症患者生存预后、免疫微环境、免疫治疗和癌症药物治疗中的作用机制  

Analysis of DSCC1 in Survival Prognosis,Immune Microenvironment,Immunotherapy and Cancer Drug Therapy in Cancer Patients

作　　者：龚洲平 王宁军 黄亮 龙斐 GONG Zhouping;WANG Ningjun;HUANG Liang(The Second Department of Respiratory Medicine,Anhua County People's Hospital,Yiyang Hunan 413500)

机构地区：[1]安化县人民医院呼吸二科,湖南益阳413500 [2]安化县人民医院病理科,湖南益阳413500

出　　处：《医学临床研究》2024年第12期1836-1840,共5页Journal of Clinical Research

基　　金：湖南省卫生健康委科研项目(编号:202103021743)。

摘　　要：【目的】探讨DNA复制和姐妹染色单体内聚因子1(DSCC1)在癌症患者生存预后、免疫微环境、免疫治疗和癌症药物治疗中的作用机制。【方法】采用癌症基因组图谱(TCGA)、基因型组织表达(GTEx)、人蛋白图谱(HPA)、肿瘤免疫评估资源2.0(TIMER2.0)、单细胞测序数据库(CancerSEA)、基因/蛋白相互作用搜索工具(STRING)、GEO免疫治疗队列和GDSC药敏数据库分析DSCC1在癌症患者生存预后、免疫微环境、免疫治疗和癌症药物治疗中的作用机制。【结果】DSCC1 mRNA在25种不同类型的癌症组织中高表达,与11种癌症患者的预后不良相关。免疫微环境结果显示:DSCC1 mRNA表达与多种免疫细胞显著相关,包括各种类型的T辅助细胞、嗜酸性粒细胞、巨噬细胞、肥大细胞等。进一步的研究表明,DSCC1 mRNA表达异常的患者有望在免疫治疗的基础上获得更好的疗效。富集分析显示:DSCC1 mRNA表达与细胞周期、p53信号通路等显著相关。【结论】DSCC1是癌症发生、发展、诊治的关键分子,其影响肺腺癌的药物治疗效果,DSCC1在多种癌症中起重要作用。【Objective】To investigate the role of DNA replication and sister chromatid cohesion factor 1(DSCC1)in survival prognosis,immune microenvironment,immunotherapy and cancer drug therapy in cancer patients.【Methods】Cancer Genome Atlas(TCGA),Genotypic Tissue Expression(GTEx),Human Protein Atlas(HPA),Tumor Immune Evaluation Resource 2.0(TIMER2.0),single cell sequencing database(CancerSEA),Interactive gene/protein Search tool(STRING),GEO immunotherapy cohort and GDSC drug sensitive database agents were used to analyze the role of DSCC1 in survival prognosis,immune microenvironment,immunotherapy and cancer drug therapy in cancer patients.【Results】DSCC1 mRNA was highly expressed in 25 different types of cancer tissues and was associated with poor prognosis in patients with 11 types of cancer.The results of immunomicroenvironment research showed that the mRNA expression of DSCC1 was significantly correlated with a variety of immune cells,including various types of T helper cells,eosinophils,macrophages,mast cells,etc.Further studies predicted that patients with abnormal DSCC1 expression were expected to achieve better outcomes of immunotherapy.Enrichment analysis showed that the mRNA expression of DSCC1 was significantly correlated with cell cycle and p53 signaling pathway.【Conclusion】DSCC1 is a key molecule in the occurrence,development,diagnosis and treatment of cancer,and it affects the therapeutic effect of lung adenocarcinoma.DSCC1 plays an important role in a variety of cancers.

关 键 词：肿瘤 预后 DNA 肿瘤 免疫疗法 药物疗法 

分 类 号：R73[医药卫生—肿瘤]