CK20、p53表达与胃癌患者临床病理特征及预后的关系  

Expression of CK20 and p53 and their Relationship with Clinicopathological Features and Prognosis in Gastric Cancer Patients

作　　者：田小豆 张院院 TIAN Xiaodou;ZHANG Yuanyuan(Department of Internal Medicine,Jingbian County People's Hospital,Yulin Shaanxi 718500)

机构地区：[1]靖边县人民医院内科,陕西榆林718500 [2]榆林市第一医院病理科,陕西榆林718000

出　　处：《医学临床研究》2024年第12期1864-1866,共3页Journal of Clinical Research

摘　　要：【目的】探讨细胞角蛋白20(CK20)、p53表达与胃癌患者临床病理特征及预后的关系。【方法】选择70例首次确诊为胃癌且进行胃癌切除术的患者,对患者癌组织及癌旁组织的CK20与p53表达情况进行分析,探讨二者表达情况与临床病理特征的关联性,并采用Cox分析二者对患者预后的影响。【结果】胃癌患者癌组织中CK20、p53蛋白阳性率均高于癌旁组织(P<0.05)。Ⅲ期、低分化、淋巴结转移患者癌组织中CK20、p53蛋白阳性表达率高于Ⅰ/Ⅱ期、中/高分化、淋巴结未转移患者(P<0.05)。随访1年,70例患者失访3例,剩余67例患者中死亡15例,病死率为22.39%(15/67)。Cox分析结果显示,Ⅲ期、低分化、淋巴结转移、p53蛋白阳性表达、CK20蛋白阳性表达均为胃癌患者预后的影响因素(P<0.05)。【结论】胃癌患者癌组织中的p53和CK20蛋白表达情况与肿瘤的分化程度、淋巴结转移情况、临床分期以及患者的预后情况显著相关。【Objective】To explore the relationship of the clinicopathological features and prognosis with the expression of cytokeratin 20(CK20)and p53 in gastric cancer patients.【Methods】Seventy patients who were diagnosed with gastric cancer for the first time and underwent gastric cancer resection were selected for the study.The levels of CK20 and p53 in the cancerous tissues and para-cancerous tissues of the patients were analyzed to investigate the association of the expression of the two with the clinicopathological features,further the effects of the two on the prognosis of the patients were analyzed by Cox.【Results】The percentage of CK20 and p53 protein positivity in cancer tissues of gastric cancer patients was higher than that in para-cancerous tissues(P<0.05).The percentage of CK20 and p53 protein positive expression in cancer tissues of patients with stageⅢ,low differentiation,and lymph node metastasis was higher than that of patients with stageⅠ/Ⅱ,middle/high differentiation,and lymph nodes without metastasis(P<0.05).After 1 year of follow-up,3 out of 70 patients were lost,and 15 out of the remaining 67 patients died,with a case-fatality rate of 22.39%(15/67).The results of Cox analysis showed that stageⅢ,poorly differentiated,lymph node metastasis,p53 protein positivity,and CK20 protein positivity were all influencing factors in the prognosis of patients with gastric cancer(P<0.05).【Conclusion】The expression levels of p53 and CK20 proteins in cancer tissues of gastric cancer patients showed a close correlation with the degree of differentiation of the tumor,the presence of lymph node metastasis,the clinical stage,and the prognosis of the patients.

关 键 词：胃肿瘤 角蛋白质类 肿瘤抑制蛋白质P53 预后 

分 类 号：R735.2[医药卫生—肿瘤]